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Randomized trial examining effectiveness of lifestyle intervention in reducing gestational diabetes in high risk Chinese pregnant women in Hong Kong

Gestational diabetes mellitus (GDM) is of public health concern. This trial examined whether a clinically proven lifestyle modification program (LMP) in early pregnancy was superior to routine antenatal care in improving GDM, maternal and infant outcomes. Chinese pregnant women at risk of GDM (n = 2...

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Autores principales: Chan, Ruth Suk-Mei, Tam, Wing-Hung, Ho, Ivan Chak-Hang, Kwan, Macy Wai-Chi, Li, Liz Sin, Sea, Mandy Man-Mei, Woo, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138708/
https://www.ncbi.nlm.nih.gov/pubmed/30218012
http://dx.doi.org/10.1038/s41598-018-32285-6
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author Chan, Ruth Suk-Mei
Tam, Wing-Hung
Ho, Ivan Chak-Hang
Kwan, Macy Wai-Chi
Li, Liz Sin
Sea, Mandy Man-Mei
Woo, Jean
author_facet Chan, Ruth Suk-Mei
Tam, Wing-Hung
Ho, Ivan Chak-Hang
Kwan, Macy Wai-Chi
Li, Liz Sin
Sea, Mandy Man-Mei
Woo, Jean
author_sort Chan, Ruth Suk-Mei
collection PubMed
description Gestational diabetes mellitus (GDM) is of public health concern. This trial examined whether a clinically proven lifestyle modification program (LMP) in early pregnancy was superior to routine antenatal care in improving GDM, maternal and infant outcomes. Chinese pregnant women at risk of GDM (n = 220) were recruited at or before 12-week gestation and randomized to either a LMP group or a routine care control group. Eighty subjects completed a dietitian-led LMP including dietary and exercise components from early pregnancy till 24-week gestation. Data were compared with those of 86 control subjects. Twenty three (26.7%) control subjects and 20 (25.0%) LMP subjects developed GDM (p = 0.798). The proportion of infants born large for gestational age and macrosomia was similar between groups. The LMP group showed a lower proportion of excessive gestational weight gain (GWG). Subgroup analysis suggested that those with higher LMP adherence showed more desirable dietary composition and energy intake, and lower proportion of excessive GWG compared with the low LMP adherence group and the control group. The potential effect of LMP on GDM and other maternal and infant outcomes, in particular GWG, as well as barriers for making lifestyle changes warrant further investigations (ClinicalTrials.gov NCT02368600).
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spelling pubmed-61387082018-09-15 Randomized trial examining effectiveness of lifestyle intervention in reducing gestational diabetes in high risk Chinese pregnant women in Hong Kong Chan, Ruth Suk-Mei Tam, Wing-Hung Ho, Ivan Chak-Hang Kwan, Macy Wai-Chi Li, Liz Sin Sea, Mandy Man-Mei Woo, Jean Sci Rep Article Gestational diabetes mellitus (GDM) is of public health concern. This trial examined whether a clinically proven lifestyle modification program (LMP) in early pregnancy was superior to routine antenatal care in improving GDM, maternal and infant outcomes. Chinese pregnant women at risk of GDM (n = 220) were recruited at or before 12-week gestation and randomized to either a LMP group or a routine care control group. Eighty subjects completed a dietitian-led LMP including dietary and exercise components from early pregnancy till 24-week gestation. Data were compared with those of 86 control subjects. Twenty three (26.7%) control subjects and 20 (25.0%) LMP subjects developed GDM (p = 0.798). The proportion of infants born large for gestational age and macrosomia was similar between groups. The LMP group showed a lower proportion of excessive gestational weight gain (GWG). Subgroup analysis suggested that those with higher LMP adherence showed more desirable dietary composition and energy intake, and lower proportion of excessive GWG compared with the low LMP adherence group and the control group. The potential effect of LMP on GDM and other maternal and infant outcomes, in particular GWG, as well as barriers for making lifestyle changes warrant further investigations (ClinicalTrials.gov NCT02368600). Nature Publishing Group UK 2018-09-14 /pmc/articles/PMC6138708/ /pubmed/30218012 http://dx.doi.org/10.1038/s41598-018-32285-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chan, Ruth Suk-Mei
Tam, Wing-Hung
Ho, Ivan Chak-Hang
Kwan, Macy Wai-Chi
Li, Liz Sin
Sea, Mandy Man-Mei
Woo, Jean
Randomized trial examining effectiveness of lifestyle intervention in reducing gestational diabetes in high risk Chinese pregnant women in Hong Kong
title Randomized trial examining effectiveness of lifestyle intervention in reducing gestational diabetes in high risk Chinese pregnant women in Hong Kong
title_full Randomized trial examining effectiveness of lifestyle intervention in reducing gestational diabetes in high risk Chinese pregnant women in Hong Kong
title_fullStr Randomized trial examining effectiveness of lifestyle intervention in reducing gestational diabetes in high risk Chinese pregnant women in Hong Kong
title_full_unstemmed Randomized trial examining effectiveness of lifestyle intervention in reducing gestational diabetes in high risk Chinese pregnant women in Hong Kong
title_short Randomized trial examining effectiveness of lifestyle intervention in reducing gestational diabetes in high risk Chinese pregnant women in Hong Kong
title_sort randomized trial examining effectiveness of lifestyle intervention in reducing gestational diabetes in high risk chinese pregnant women in hong kong
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138708/
https://www.ncbi.nlm.nih.gov/pubmed/30218012
http://dx.doi.org/10.1038/s41598-018-32285-6
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