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Nrf2 activation attenuates the early suppression of mitochondrial respiration due to the α-synuclein overexpression

BACKGROUND: α-synuclein (SNCA) accumulation in the substantia nigra is one of the characteristic pathologies of Parkinson's disease (PD). A53T missense mutations in the SNCA gene has been proved to enhance the expression of SNCA and accelerate the onset of PD. Mitochondrial dysfunction in SNCA...

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Detalles Bibliográficos
Autores principales:	Fu, Mu-Hui, Wu, Chih-Wei, Lee, Yu-Chi, Hung, Chun-Ying, Chen, I-Chun, Wu, Kay L.H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Chang Gung University 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138761/ https://www.ncbi.nlm.nih.gov/pubmed/30080657 http://dx.doi.org/10.1016/j.bj.2018.02.005

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