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Clear cell variant squamous cell carcinoma of temporal bone: Case report and literature review

INTRODUCTION: Squamous cell carcinoma (SCC) of the temporal bone is a rare malignancy. Clear cell SCC is a rare variant of SCC of temporal bone in which no clear risk factor has been suggested as possible etiology. Otalgia, otorrhea, and hearing loss are the usual presenting symptoms of SCC of the t...

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Autores principales: AlEnazi, Abdulaziz S., Alwadi, Fahad A., AlOqaili, Yazeed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138846/
https://www.ncbi.nlm.nih.gov/pubmed/30218819
http://dx.doi.org/10.1016/j.ijscr.2018.08.040
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author AlEnazi, Abdulaziz S.
Alwadi, Fahad A.
AlOqaili, Yazeed A.
author_facet AlEnazi, Abdulaziz S.
Alwadi, Fahad A.
AlOqaili, Yazeed A.
author_sort AlEnazi, Abdulaziz S.
collection PubMed
description INTRODUCTION: Squamous cell carcinoma (SCC) of the temporal bone is a rare malignancy. Clear cell SCC is a rare variant of SCC of temporal bone in which no clear risk factor has been suggested as possible etiology. Otalgia, otorrhea, and hearing loss are the usual presenting symptoms of SCC of the temporal bone. PRESENTATION OF CASE: This is a case is of a 62-year-old female who presented with a 6 months’ history of experiencing intermittent left hearing disturbance, loss of balance, persistent left tinnitus, left otalgia radiating to the lateral neck and post auricular swelling. Histology showed clear cell variant, well differentiated SCC. The patient’s tumor was found to be non-resectable due to the extensive invasion. The patient was referred for palliative therapy by medical and radiation oncology, however, the patient couldn't tolerate it. One month later she passed away. DISCUSSION: SCC of the temporal bone is a challenging clinical entity. It is diagnosed mainly by clinical and radiological assessment, and deep biopsies are used to confirm the diagnosis. Temporal bone SCC is usually diagnosed late due to delayed presentation. This case of temporal bone SCC was aggressive in nature and presentation. The presentation was different from the known triad of symptoms of temporal bone SCC which is offensive otorrhea, pain, and bleeding. CONCLUSION: This case showed a very destructive and bizarre clinical presentation but more report of cases is needed to have a better characterization of the clinical presentation and prognosis of this variant of SCC of temporal bone.
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spelling pubmed-61388462018-09-17 Clear cell variant squamous cell carcinoma of temporal bone: Case report and literature review AlEnazi, Abdulaziz S. Alwadi, Fahad A. AlOqaili, Yazeed A. Int J Surg Case Rep Article INTRODUCTION: Squamous cell carcinoma (SCC) of the temporal bone is a rare malignancy. Clear cell SCC is a rare variant of SCC of temporal bone in which no clear risk factor has been suggested as possible etiology. Otalgia, otorrhea, and hearing loss are the usual presenting symptoms of SCC of the temporal bone. PRESENTATION OF CASE: This is a case is of a 62-year-old female who presented with a 6 months’ history of experiencing intermittent left hearing disturbance, loss of balance, persistent left tinnitus, left otalgia radiating to the lateral neck and post auricular swelling. Histology showed clear cell variant, well differentiated SCC. The patient’s tumor was found to be non-resectable due to the extensive invasion. The patient was referred for palliative therapy by medical and radiation oncology, however, the patient couldn't tolerate it. One month later she passed away. DISCUSSION: SCC of the temporal bone is a challenging clinical entity. It is diagnosed mainly by clinical and radiological assessment, and deep biopsies are used to confirm the diagnosis. Temporal bone SCC is usually diagnosed late due to delayed presentation. This case of temporal bone SCC was aggressive in nature and presentation. The presentation was different from the known triad of symptoms of temporal bone SCC which is offensive otorrhea, pain, and bleeding. CONCLUSION: This case showed a very destructive and bizarre clinical presentation but more report of cases is needed to have a better characterization of the clinical presentation and prognosis of this variant of SCC of temporal bone. Elsevier 2018-09-01 /pmc/articles/PMC6138846/ /pubmed/30218819 http://dx.doi.org/10.1016/j.ijscr.2018.08.040 Text en © 2018 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
AlEnazi, Abdulaziz S.
Alwadi, Fahad A.
AlOqaili, Yazeed A.
Clear cell variant squamous cell carcinoma of temporal bone: Case report and literature review
title Clear cell variant squamous cell carcinoma of temporal bone: Case report and literature review
title_full Clear cell variant squamous cell carcinoma of temporal bone: Case report and literature review
title_fullStr Clear cell variant squamous cell carcinoma of temporal bone: Case report and literature review
title_full_unstemmed Clear cell variant squamous cell carcinoma of temporal bone: Case report and literature review
title_short Clear cell variant squamous cell carcinoma of temporal bone: Case report and literature review
title_sort clear cell variant squamous cell carcinoma of temporal bone: case report and literature review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138846/
https://www.ncbi.nlm.nih.gov/pubmed/30218819
http://dx.doi.org/10.1016/j.ijscr.2018.08.040
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