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Reduced intrinsic DNA curvature leads to increased mutation rate
BACKGROUND: Mutation rates vary across the genome. Many trans factors that influence mutation rates have been identified, as have specific sequence motifs at the 1–7-bp scale, but cis elements remain poorly characterized. The lack of understanding regarding why different sequences have different mut...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138893/ https://www.ncbi.nlm.nih.gov/pubmed/30217230 http://dx.doi.org/10.1186/s13059-018-1525-y |