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AR–PDEF pathway promotes tumour proliferation and upregulates MYC-mediated gene transcription by promoting MAD1 degradation in ER-negative breast cancer

BACKGROUND: Androgen receptor (AR) is expressed in 60%~ 70% oestrogen receptor (ER)-negative breast cancer (BC) cases and promotes the growth of this cancer subtype. Expression of prostate-derived Ets factor (PDEF), a transcription factor, is highly restricted to epithelial cells in hormone-regulate...

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Detalles Bibliográficos
Autores principales:	Cao, Lu, Xu, Cong, Xiang, Guomin, Liu, Fang, Liu, Xiaozhen, Li, Congying, Liu, Jing, Meng, Qingxiang, Jiao, Jiao, Niu, Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138935/ https://www.ncbi.nlm.nih.gov/pubmed/30217192 http://dx.doi.org/10.1186/s12943-018-0883-0

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