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Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival

Non-exudative age-related macular degeneration (AMD) is mainly caused by the accumulation of lipofuscin and drusen on the retinal pigment epithelium (RPE). Both oxidative stress and autophagic dysfunction accelerate the deposition of lipofuscin at the RPE. One of the key regulators in the response a...

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Detalles Bibliográficos
Autores principales:	Saito, Yuichi, Kuse, Yoshiki, Inoue, Yuki, Nakamura, Shinsuke, Hara, Hideaki, Shimazawa, Masamitsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138993/ https://www.ncbi.nlm.nih.gov/pubmed/30216854 http://dx.doi.org/10.1016/j.redox.2018.09.004

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