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Determination of Hepatocellular Carcinoma and Characterization of Hepatic Focal Lesions with Adaptive Multi-Exponential Intravoxel Incoherent Motion Model

PURPOSE: To distinguish hepatocellular carcinoma (HCC) from other types of hepatic lesions with the adaptive multi-exponential IVIM model. METHODS: 94 hepatic focal lesions, including 38 HCC, 16 metastasis, 12 focal nodular hyperplasia, 13 cholangiocarcinoma, and 15 hemangioma, were examined in this...

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Autores principales: Zhang, Hong-Xia, Zhang, Xiu-Shi, Kuai, Zi-Xiang, Zhou, Yang, Sun, Yun-Feng, Ba, Zhi-Chang, He, Kuang-Bang, Sang, Xi-Qiao, Yao, Yuan-Fei, Chu, Chun-Yu, Zhu, Yue-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139005/
https://www.ncbi.nlm.nih.gov/pubmed/30216762
http://dx.doi.org/10.1016/j.tranon.2018.08.011
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author Zhang, Hong-Xia
Zhang, Xiu-Shi
Kuai, Zi-Xiang
Zhou, Yang
Sun, Yun-Feng
Ba, Zhi-Chang
He, Kuang-Bang
Sang, Xi-Qiao
Yao, Yuan-Fei
Chu, Chun-Yu
Zhu, Yue-Min
author_facet Zhang, Hong-Xia
Zhang, Xiu-Shi
Kuai, Zi-Xiang
Zhou, Yang
Sun, Yun-Feng
Ba, Zhi-Chang
He, Kuang-Bang
Sang, Xi-Qiao
Yao, Yuan-Fei
Chu, Chun-Yu
Zhu, Yue-Min
author_sort Zhang, Hong-Xia
collection PubMed
description PURPOSE: To distinguish hepatocellular carcinoma (HCC) from other types of hepatic lesions with the adaptive multi-exponential IVIM model. METHODS: 94 hepatic focal lesions, including 38 HCC, 16 metastasis, 12 focal nodular hyperplasia, 13 cholangiocarcinoma, and 15 hemangioma, were examined in this study. Diffusion-weighted images were acquired with 13 b values (b = 0, 3, …, 500 s/mm(2)) to measure the adaptive multi-exponential IVIM parameters, namely, pure diffusion coefficient (D), diffusion fraction (f(d)), pseudo-diffusion coefficient (D(i)*) and perfusion-related diffusion fraction (f(i)) of the ith perfusion component. Comparison of the parameters of and their diagnostic performance was determined using Mann-Whitney U test, independent-sample t test, one-way analysis of variance, Z test and receiver-operating characteristic analysis. RESULTS: D, D(1)* and D(2)* presented significantly difference between HCCs and other hepatic lesions, whereas f(d), f(1) and f(2) did not show statistical differences. In the differential diagnosis of HCCs from other hepatic lesions, D(2)* (AUC, 0.927) provided best diagnostic performance among all parameters. Additionally, the number of exponential terms in the model was also an important indicator for distinguishing HCCs from other hepatic lesions. In the benign and malignant analysis, D gave the greatest AUC values, 0.895 or 0.853, for differentiation between malignant and benign lesions with three or two exponential terms. Most parameters were not significantly different between hypovascular and hypervascular lesions. For multiple comparisons, significant differences of D, D(1)* or D(2)* were found between certain lesion types. CONCLUSION: The adaptive multi-exponential IVIM model was useful and reliable to distinguish HCC from other hepatic lesions.
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spelling pubmed-61390052018-09-19 Determination of Hepatocellular Carcinoma and Characterization of Hepatic Focal Lesions with Adaptive Multi-Exponential Intravoxel Incoherent Motion Model Zhang, Hong-Xia Zhang, Xiu-Shi Kuai, Zi-Xiang Zhou, Yang Sun, Yun-Feng Ba, Zhi-Chang He, Kuang-Bang Sang, Xi-Qiao Yao, Yuan-Fei Chu, Chun-Yu Zhu, Yue-Min Transl Oncol Original article PURPOSE: To distinguish hepatocellular carcinoma (HCC) from other types of hepatic lesions with the adaptive multi-exponential IVIM model. METHODS: 94 hepatic focal lesions, including 38 HCC, 16 metastasis, 12 focal nodular hyperplasia, 13 cholangiocarcinoma, and 15 hemangioma, were examined in this study. Diffusion-weighted images were acquired with 13 b values (b = 0, 3, …, 500 s/mm(2)) to measure the adaptive multi-exponential IVIM parameters, namely, pure diffusion coefficient (D), diffusion fraction (f(d)), pseudo-diffusion coefficient (D(i)*) and perfusion-related diffusion fraction (f(i)) of the ith perfusion component. Comparison of the parameters of and their diagnostic performance was determined using Mann-Whitney U test, independent-sample t test, one-way analysis of variance, Z test and receiver-operating characteristic analysis. RESULTS: D, D(1)* and D(2)* presented significantly difference between HCCs and other hepatic lesions, whereas f(d), f(1) and f(2) did not show statistical differences. In the differential diagnosis of HCCs from other hepatic lesions, D(2)* (AUC, 0.927) provided best diagnostic performance among all parameters. Additionally, the number of exponential terms in the model was also an important indicator for distinguishing HCCs from other hepatic lesions. In the benign and malignant analysis, D gave the greatest AUC values, 0.895 or 0.853, for differentiation between malignant and benign lesions with three or two exponential terms. Most parameters were not significantly different between hypovascular and hypervascular lesions. For multiple comparisons, significant differences of D, D(1)* or D(2)* were found between certain lesion types. CONCLUSION: The adaptive multi-exponential IVIM model was useful and reliable to distinguish HCC from other hepatic lesions. Neoplasia Press 2018-09-11 /pmc/articles/PMC6139005/ /pubmed/30216762 http://dx.doi.org/10.1016/j.tranon.2018.08.011 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original article
Zhang, Hong-Xia
Zhang, Xiu-Shi
Kuai, Zi-Xiang
Zhou, Yang
Sun, Yun-Feng
Ba, Zhi-Chang
He, Kuang-Bang
Sang, Xi-Qiao
Yao, Yuan-Fei
Chu, Chun-Yu
Zhu, Yue-Min
Determination of Hepatocellular Carcinoma and Characterization of Hepatic Focal Lesions with Adaptive Multi-Exponential Intravoxel Incoherent Motion Model
title Determination of Hepatocellular Carcinoma and Characterization of Hepatic Focal Lesions with Adaptive Multi-Exponential Intravoxel Incoherent Motion Model
title_full Determination of Hepatocellular Carcinoma and Characterization of Hepatic Focal Lesions with Adaptive Multi-Exponential Intravoxel Incoherent Motion Model
title_fullStr Determination of Hepatocellular Carcinoma and Characterization of Hepatic Focal Lesions with Adaptive Multi-Exponential Intravoxel Incoherent Motion Model
title_full_unstemmed Determination of Hepatocellular Carcinoma and Characterization of Hepatic Focal Lesions with Adaptive Multi-Exponential Intravoxel Incoherent Motion Model
title_short Determination of Hepatocellular Carcinoma and Characterization of Hepatic Focal Lesions with Adaptive Multi-Exponential Intravoxel Incoherent Motion Model
title_sort determination of hepatocellular carcinoma and characterization of hepatic focal lesions with adaptive multi-exponential intravoxel incoherent motion model
topic Original article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139005/
https://www.ncbi.nlm.nih.gov/pubmed/30216762
http://dx.doi.org/10.1016/j.tranon.2018.08.011
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