Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult Rats

Ciliary neurotrophic factor (CNTF) promotes survival and enhances long-distance regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene therapy targeting corticospinal neurons (CSN) in motor-related regions of the cerebral cortex promotes plasticity and regrowth of...

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Detalles Bibliográficos
Autores principales: Hodgetts, Stuart I., Yoon, Jun Han, Fogliani, Alysia, Akinpelu, Emmanuel A., Baron-Heeris, Danii, Houwers, Imke G. J., Wheeler, Lachlan P. G., Majda, Bernadette T., Santhakumar, Sreya, Lovett, Sarah J., Duce, Emma, Pollett, Margaret A., Wiseman, Tylie M., Fehily, Brooke, Harvey, Alan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139201/
https://www.ncbi.nlm.nih.gov/pubmed/30245710
http://dx.doi.org/10.1155/2018/9828725

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