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The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra. The precise mechanism underlying pathogenesis of PD is not fully understood, but it has been widely accepted that excessive reactive o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139203/ https://www.ncbi.nlm.nih.gov/pubmed/30245802 http://dx.doi.org/10.1155/2018/9163040 |
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author | Weng, Minrui Xie, Xiaoji Liu, Chao Lim, Kah-Leong Zhang, Cheng-wu Li, Lin |
author_facet | Weng, Minrui Xie, Xiaoji Liu, Chao Lim, Kah-Leong Zhang, Cheng-wu Li, Lin |
author_sort | Weng, Minrui |
collection | PubMed |
description | Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra. The precise mechanism underlying pathogenesis of PD is not fully understood, but it has been widely accepted that excessive reactive oxygen species (ROS) are the key mediator of PD pathogenesis. The causative factors of PD such as gene mutation, neuroinflammation, and iron accumulation all could induce ROS generation, and the later would mediate the dopaminergic neuron death by causing oxidation protein, lipids, and other macromolecules in the cells. Obviously, it is of mechanistic and therapeutic significance to understand where ROS are derived and how ROS induce dopaminergic neuron damage. In the present review, we try to summarize and discuss the main source of ROS in PD and the key pathways through which ROS mediate DA neuron death. |
format | Online Article Text |
id | pubmed-6139203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-61392032018-09-23 The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson's Disease Weng, Minrui Xie, Xiaoji Liu, Chao Lim, Kah-Leong Zhang, Cheng-wu Li, Lin Parkinsons Dis Review Article Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra. The precise mechanism underlying pathogenesis of PD is not fully understood, but it has been widely accepted that excessive reactive oxygen species (ROS) are the key mediator of PD pathogenesis. The causative factors of PD such as gene mutation, neuroinflammation, and iron accumulation all could induce ROS generation, and the later would mediate the dopaminergic neuron death by causing oxidation protein, lipids, and other macromolecules in the cells. Obviously, it is of mechanistic and therapeutic significance to understand where ROS are derived and how ROS induce dopaminergic neuron damage. In the present review, we try to summarize and discuss the main source of ROS in PD and the key pathways through which ROS mediate DA neuron death. Hindawi 2018-09-02 /pmc/articles/PMC6139203/ /pubmed/30245802 http://dx.doi.org/10.1155/2018/9163040 Text en Copyright © 2018 Minrui Weng et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Weng, Minrui Xie, Xiaoji Liu, Chao Lim, Kah-Leong Zhang, Cheng-wu Li, Lin The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson's Disease |
title | The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson's Disease |
title_full | The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson's Disease |
title_fullStr | The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson's Disease |
title_full_unstemmed | The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson's Disease |
title_short | The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson's Disease |
title_sort | sources of reactive oxygen species and its possible role in the pathogenesis of parkinson's disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139203/ https://www.ncbi.nlm.nih.gov/pubmed/30245802 http://dx.doi.org/10.1155/2018/9163040 |
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