A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention

Previous studies in animal models of cocaine craving have delineated broad changes in DNA methylation profiles in the nucleus accumbens. A crucial factor for progress in behavioral and mental health epigenetics is the discovery of epigenetic markers in peripheral tissues. Several studies in primates...

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Autores principales: Lax, Elad, Warhaftig, Gal, Ohana, David, Maayan, Rachel, Delayahu, Yael, Roska, Paola, Ponizovsky, Alexander M., Weizman, Abraham, Yadid, Gal, Szyf, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139343/
https://www.ncbi.nlm.nih.gov/pubmed/30250424
http://dx.doi.org/10.3389/fnmol.2018.00322
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author Lax, Elad
Warhaftig, Gal
Ohana, David
Maayan, Rachel
Delayahu, Yael
Roska, Paola
Ponizovsky, Alexander M.
Weizman, Abraham
Yadid, Gal
Szyf, Moshe
author_facet Lax, Elad
Warhaftig, Gal
Ohana, David
Maayan, Rachel
Delayahu, Yael
Roska, Paola
Ponizovsky, Alexander M.
Weizman, Abraham
Yadid, Gal
Szyf, Moshe
author_sort Lax, Elad
collection PubMed
description Previous studies in animal models of cocaine craving have delineated broad changes in DNA methylation profiles in the nucleus accumbens. A crucial factor for progress in behavioral and mental health epigenetics is the discovery of epigenetic markers in peripheral tissues. Several studies in primates and humans have associated differences in behavioral phenotypes with changes in DNA methylation in T cells and brain. Herein, we present a pilot study (n = 27) showing that the T cell DNA methylation profile differentiates persons with a substance use disorder from controls. Intervention with dehydroepiandrosterone (DHEA), previously shown to have a long-term therapeutic effect on human addicts herein resulted in reversal of DNA methylation changes in genes related to pathways associated with the addictive state.
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spelling pubmed-61393432018-09-24 A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention Lax, Elad Warhaftig, Gal Ohana, David Maayan, Rachel Delayahu, Yael Roska, Paola Ponizovsky, Alexander M. Weizman, Abraham Yadid, Gal Szyf, Moshe Front Mol Neurosci Neuroscience Previous studies in animal models of cocaine craving have delineated broad changes in DNA methylation profiles in the nucleus accumbens. A crucial factor for progress in behavioral and mental health epigenetics is the discovery of epigenetic markers in peripheral tissues. Several studies in primates and humans have associated differences in behavioral phenotypes with changes in DNA methylation in T cells and brain. Herein, we present a pilot study (n = 27) showing that the T cell DNA methylation profile differentiates persons with a substance use disorder from controls. Intervention with dehydroepiandrosterone (DHEA), previously shown to have a long-term therapeutic effect on human addicts herein resulted in reversal of DNA methylation changes in genes related to pathways associated with the addictive state. Frontiers Media S.A. 2018-09-10 /pmc/articles/PMC6139343/ /pubmed/30250424 http://dx.doi.org/10.3389/fnmol.2018.00322 Text en Copyright © 2018 Lax, Warhaftig, Ohana, Maayan, Delayahu, Roska, Ponizovsky, Weizman, Yadid and Szyf. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Lax, Elad
Warhaftig, Gal
Ohana, David
Maayan, Rachel
Delayahu, Yael
Roska, Paola
Ponizovsky, Alexander M.
Weizman, Abraham
Yadid, Gal
Szyf, Moshe
A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention
title A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention
title_full A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention
title_fullStr A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention
title_full_unstemmed A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention
title_short A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention
title_sort dna methylation signature of addiction in t cells and its reversal with dhea intervention
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139343/
https://www.ncbi.nlm.nih.gov/pubmed/30250424
http://dx.doi.org/10.3389/fnmol.2018.00322
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