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The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho–Ser-621 in the C terminus of CRAF

The dimerization-driven paradoxical activation of RAF proto-oncogene Ser/Thr kinase (RAF) is the predominant cause of drug resistance and toxicity in cancer therapies with RAF inhibitors. The scaffold protein 14-3-3, which binds to the RAF C terminus, is essential for RAF activation under physiologi...

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Detalles Bibliográficos
Autores principales:	Yuan, Jimin, Ng, Wan Hwa, Yap, Jiajun, Chia, Brandon, Huang, Xuchao, Wang, Mei, Hu, Jiancheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139560/ https://www.ncbi.nlm.nih.gov/pubmed/30030377 http://dx.doi.org/10.1074/jbc.RA118.004597

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