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Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors

[Image: see text] Aspartate (Asp) derivatives are privileged compounds for investigating the roles governed by excitatory amino acid transporters (EAATs) in glutamatergic neurotransmission. Here, we report the synthesis of various Asp derivatives with (cyclo)alkyloxy and (hetero)aryloxy substituents...

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Detalles Bibliográficos
Autores principales:	Fu, Haigen, Zhang, Jielin, Tepper, Pieter G., Bunch, Lennart, Jensen, Anders A., Poelarends, Gerrit J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139576/ https://www.ncbi.nlm.nih.gov/pubmed/30011368 http://dx.doi.org/10.1021/acs.jmedchem.8b00700

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