Computational Model of Chimeric Antigen Receptors Explains Site-Specific Phosphorylation Kinetics

Chimeric antigen receptors (CARs) have recently been approved for the treatment of hematological malignancies, but our lack of understanding of the basic mechanisms that activate these proteins has made it difficult to optimize and control CAR-based therapies. In this study, we use phosphoproteomic...

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Detalles Bibliográficos
Autores principales: Rohrs, Jennifer A., Zheng, Dongqing, Graham, Nicholas A., Wang, Pin, Finley, Stacey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2018
Materias:
Systems Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139883/
https://www.ncbi.nlm.nih.gov/pubmed/30197180
http://dx.doi.org/10.1016/j.bpj.2018.08.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139883/
https://www.ncbi.nlm.nih.gov/pubmed/30197180
http://dx.doi.org/10.1016/j.bpj.2018.08.018

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