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The Iron-Klotho-VDR Axis Is a Major Determinant of Proximal Convoluted Tubule Injury in Haptoglobin 2-2 Genotype Diabetic Nephropathy Patients and Mice

The haptoglobin (Hp) genotype (1-1 and 2-2) is a major determinant of nephropathy progression in diabetes mellitus patients. Hp 2-2 diabetic mice have impaired Hb clearance and increased iron deposits and oxidative stress in the proximal tubules (PCT), leading to increased renal injury. However, the...

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Detalles Bibliográficos
Autores principales:	Dahan, Inbal, Thawho, Nadia, Farber, Evgeny, Nakhoul, Nakhoul, Asleh, Rabea, Levy, Andrew P., Li, Yan Chun, Ben-Izhak, Ofer, Nakhoul, Farid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140001/ https://www.ncbi.nlm.nih.gov/pubmed/30250850 http://dx.doi.org/10.1155/2018/7163652

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