SNRP-27, the C. elegans homolog of the tri-snRNP 27K protein, has a role in 5′ splice site positioning in the spliceosome

The tri-snRNP 27K protein is a component of the human U4/U6-U5 tri-snRNP and contains an N-terminal phosphorylated RS domain. In a forward genetic screen in C. elegans, we previously identified a dominant mutation, M141T, in the highly-conserved C-terminal region of this protein. The mutant allele p...

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Detalles Bibliográficos
Autores principales: Zahler, Alan M., Rogel, Lucero E., Glover, Marissa L., Yitiz, Samira, Ragle, J. Matthew, Katzman, Sol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140464/
https://www.ncbi.nlm.nih.gov/pubmed/30006499
http://dx.doi.org/10.1261/rna.066878.118

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