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Effects of treadmill running in a rat model of chronic kidney disease

Chronic kidney disease (CKD) progression results in musculoskeletal dysfunction that is associated with a higher likelihood of hospitalization and is predictive of hospitalizations and mortality. Despite this, there is a lack of effective interventions to treat the musculoskeletal dysfunction. We st...

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Autores principales: Organ, J.M., Allen, M.R., Myers-White, A., Elkhatib, W., O'Neill, K.D., Chen, N.X., Moe, S.M., Avin, K.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140622/
https://www.ncbi.nlm.nih.gov/pubmed/30229133
http://dx.doi.org/10.1016/j.bbrep.2018.09.001
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author Organ, J.M.
Allen, M.R.
Myers-White, A.
Elkhatib, W.
O'Neill, K.D.
Chen, N.X.
Moe, S.M.
Avin, K.G.
author_facet Organ, J.M.
Allen, M.R.
Myers-White, A.
Elkhatib, W.
O'Neill, K.D.
Chen, N.X.
Moe, S.M.
Avin, K.G.
author_sort Organ, J.M.
collection PubMed
description Chronic kidney disease (CKD) progression results in musculoskeletal dysfunction that is associated with a higher likelihood of hospitalization and is predictive of hospitalizations and mortality. Despite this, there is a lack of effective interventions to treat the musculoskeletal dysfunction. We studied treadmill running as an intervention to improve musculoskeletal health in a translational rat model that has slowly progressive CKD. CKD rats were subjected to treadmill exercise or no treadmill exercise for 10 weeks (n = 8 each group). Animals ran for 60 min, 5 times per week starting at a speed of 8 m/min and ending at 18 m/min (1 m/min increase/week). Treadmill training had no effect on muscle strength (assessed as maximally stimulated torque), half-relaxation time (time from peak torque to 50%) or muscle cross-sectional area. Overall, there were no biochemical improvements related to CKD progression. Skeletal muscle catabolism was higher than non-exercised animals without a concomitant change in muscle synthesis markers or regeneration transcription factors. These results suggest that aerobic exercise, achieved via treadmill running was not protective in CKD animals and actually produced potentially harmful effects (increased catabolism). Given the high prevalence and dramatic musculoskeletal mobility impairment in patients with CKD, there is a clear need to understand how to effectively prescribe exercise in order to benefit the musculoskeletal system.
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spelling pubmed-61406222018-09-18 Effects of treadmill running in a rat model of chronic kidney disease Organ, J.M. Allen, M.R. Myers-White, A. Elkhatib, W. O'Neill, K.D. Chen, N.X. Moe, S.M. Avin, K.G. Biochem Biophys Rep Research Article Chronic kidney disease (CKD) progression results in musculoskeletal dysfunction that is associated with a higher likelihood of hospitalization and is predictive of hospitalizations and mortality. Despite this, there is a lack of effective interventions to treat the musculoskeletal dysfunction. We studied treadmill running as an intervention to improve musculoskeletal health in a translational rat model that has slowly progressive CKD. CKD rats were subjected to treadmill exercise or no treadmill exercise for 10 weeks (n = 8 each group). Animals ran for 60 min, 5 times per week starting at a speed of 8 m/min and ending at 18 m/min (1 m/min increase/week). Treadmill training had no effect on muscle strength (assessed as maximally stimulated torque), half-relaxation time (time from peak torque to 50%) or muscle cross-sectional area. Overall, there were no biochemical improvements related to CKD progression. Skeletal muscle catabolism was higher than non-exercised animals without a concomitant change in muscle synthesis markers or regeneration transcription factors. These results suggest that aerobic exercise, achieved via treadmill running was not protective in CKD animals and actually produced potentially harmful effects (increased catabolism). Given the high prevalence and dramatic musculoskeletal mobility impairment in patients with CKD, there is a clear need to understand how to effectively prescribe exercise in order to benefit the musculoskeletal system. Elsevier 2018-09-14 /pmc/articles/PMC6140622/ /pubmed/30229133 http://dx.doi.org/10.1016/j.bbrep.2018.09.001 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Organ, J.M.
Allen, M.R.
Myers-White, A.
Elkhatib, W.
O'Neill, K.D.
Chen, N.X.
Moe, S.M.
Avin, K.G.
Effects of treadmill running in a rat model of chronic kidney disease
title Effects of treadmill running in a rat model of chronic kidney disease
title_full Effects of treadmill running in a rat model of chronic kidney disease
title_fullStr Effects of treadmill running in a rat model of chronic kidney disease
title_full_unstemmed Effects of treadmill running in a rat model of chronic kidney disease
title_short Effects of treadmill running in a rat model of chronic kidney disease
title_sort effects of treadmill running in a rat model of chronic kidney disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140622/
https://www.ncbi.nlm.nih.gov/pubmed/30229133
http://dx.doi.org/10.1016/j.bbrep.2018.09.001
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