Cargando…

Efficacy of perineural dexamethasone with ropivacaine in thoracic paravertebral block for postoperative analgesia in elective thoracotomy: a randomized, double-blind, placebo-controlled trial

PURPOSE: The purpose of this study was to assess the efficacy of perineural dexamethasone with ropivacaine in multimodal analgesia for thoracic paravertebral block (TPVB) in patients undergoing elective thoracotomy. PATIENTS AND METHODS: Ninety-six patients undergoing thoracotomy were enrolled in th...

Descripción completa

Detalles Bibliográficos
Autores principales: Mao, Yu, Zuo, Youmei, Mei, Bin, Chen, Lijian, Liu, Xuesheng, Zhang, Zhi, Gu, Erwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140743/
https://www.ncbi.nlm.nih.gov/pubmed/30254483
http://dx.doi.org/10.2147/JPR.S164225
_version_ 1783355620522459136
author Mao, Yu
Zuo, Youmei
Mei, Bin
Chen, Lijian
Liu, Xuesheng
Zhang, Zhi
Gu, Erwei
author_facet Mao, Yu
Zuo, Youmei
Mei, Bin
Chen, Lijian
Liu, Xuesheng
Zhang, Zhi
Gu, Erwei
author_sort Mao, Yu
collection PubMed
description PURPOSE: The purpose of this study was to assess the efficacy of perineural dexamethasone with ropivacaine in multimodal analgesia for thoracic paravertebral block (TPVB) in patients undergoing elective thoracotomy. PATIENTS AND METHODS: Ninety-six patients undergoing thoracotomy were enrolled in this trial and randomized to adjuvant therapy for TPVB: group S (saline), group R (0.5% ropivacaine), or group RD (5 mg dexamethasone and 0.5% ropivacaine). Postoperative analgesia, recovery duration, and chronic pain were recorded. RESULTS: Groups R and RD spent less time in the postanaesthesia care unit, had earlier out-of-bed activity, and had shorter postoperative hospital stays compared with group S. The RD group regained consciousness faster and had lower acute pain scores and used less patient-controlled analgesia during the first 72 h after surgery compared with group S. Postthoracotomy pain was decreased in group RD (19.0%) compared with group S (47.6%) 3 months postoperatively, p = 0.050. CONCLUSION: Perineural dexamethasone with ropivacaine for TPVB improves postoperative analgesia quality, reduces recovery time, and may decrease the incidence of chronic pain after thoracotomy with an opioid-based anesthetic regimen.
format Online
Article
Text
id pubmed-6140743
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-61407432018-09-25 Efficacy of perineural dexamethasone with ropivacaine in thoracic paravertebral block for postoperative analgesia in elective thoracotomy: a randomized, double-blind, placebo-controlled trial Mao, Yu Zuo, Youmei Mei, Bin Chen, Lijian Liu, Xuesheng Zhang, Zhi Gu, Erwei J Pain Res Clinical Trial Report PURPOSE: The purpose of this study was to assess the efficacy of perineural dexamethasone with ropivacaine in multimodal analgesia for thoracic paravertebral block (TPVB) in patients undergoing elective thoracotomy. PATIENTS AND METHODS: Ninety-six patients undergoing thoracotomy were enrolled in this trial and randomized to adjuvant therapy for TPVB: group S (saline), group R (0.5% ropivacaine), or group RD (5 mg dexamethasone and 0.5% ropivacaine). Postoperative analgesia, recovery duration, and chronic pain were recorded. RESULTS: Groups R and RD spent less time in the postanaesthesia care unit, had earlier out-of-bed activity, and had shorter postoperative hospital stays compared with group S. The RD group regained consciousness faster and had lower acute pain scores and used less patient-controlled analgesia during the first 72 h after surgery compared with group S. Postthoracotomy pain was decreased in group RD (19.0%) compared with group S (47.6%) 3 months postoperatively, p = 0.050. CONCLUSION: Perineural dexamethasone with ropivacaine for TPVB improves postoperative analgesia quality, reduces recovery time, and may decrease the incidence of chronic pain after thoracotomy with an opioid-based anesthetic regimen. Dove Medical Press 2018-09-11 /pmc/articles/PMC6140743/ /pubmed/30254483 http://dx.doi.org/10.2147/JPR.S164225 Text en © 2018 Mao et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Clinical Trial Report
Mao, Yu
Zuo, Youmei
Mei, Bin
Chen, Lijian
Liu, Xuesheng
Zhang, Zhi
Gu, Erwei
Efficacy of perineural dexamethasone with ropivacaine in thoracic paravertebral block for postoperative analgesia in elective thoracotomy: a randomized, double-blind, placebo-controlled trial
title Efficacy of perineural dexamethasone with ropivacaine in thoracic paravertebral block for postoperative analgesia in elective thoracotomy: a randomized, double-blind, placebo-controlled trial
title_full Efficacy of perineural dexamethasone with ropivacaine in thoracic paravertebral block for postoperative analgesia in elective thoracotomy: a randomized, double-blind, placebo-controlled trial
title_fullStr Efficacy of perineural dexamethasone with ropivacaine in thoracic paravertebral block for postoperative analgesia in elective thoracotomy: a randomized, double-blind, placebo-controlled trial
title_full_unstemmed Efficacy of perineural dexamethasone with ropivacaine in thoracic paravertebral block for postoperative analgesia in elective thoracotomy: a randomized, double-blind, placebo-controlled trial
title_short Efficacy of perineural dexamethasone with ropivacaine in thoracic paravertebral block for postoperative analgesia in elective thoracotomy: a randomized, double-blind, placebo-controlled trial
title_sort efficacy of perineural dexamethasone with ropivacaine in thoracic paravertebral block for postoperative analgesia in elective thoracotomy: a randomized, double-blind, placebo-controlled trial
topic Clinical Trial Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140743/
https://www.ncbi.nlm.nih.gov/pubmed/30254483
http://dx.doi.org/10.2147/JPR.S164225
work_keys_str_mv AT maoyu efficacyofperineuraldexamethasonewithropivacaineinthoracicparavertebralblockforpostoperativeanalgesiainelectivethoracotomyarandomizeddoubleblindplacebocontrolledtrial
AT zuoyoumei efficacyofperineuraldexamethasonewithropivacaineinthoracicparavertebralblockforpostoperativeanalgesiainelectivethoracotomyarandomizeddoubleblindplacebocontrolledtrial
AT meibin efficacyofperineuraldexamethasonewithropivacaineinthoracicparavertebralblockforpostoperativeanalgesiainelectivethoracotomyarandomizeddoubleblindplacebocontrolledtrial
AT chenlijian efficacyofperineuraldexamethasonewithropivacaineinthoracicparavertebralblockforpostoperativeanalgesiainelectivethoracotomyarandomizeddoubleblindplacebocontrolledtrial
AT liuxuesheng efficacyofperineuraldexamethasonewithropivacaineinthoracicparavertebralblockforpostoperativeanalgesiainelectivethoracotomyarandomizeddoubleblindplacebocontrolledtrial
AT zhangzhi efficacyofperineuraldexamethasonewithropivacaineinthoracicparavertebralblockforpostoperativeanalgesiainelectivethoracotomyarandomizeddoubleblindplacebocontrolledtrial
AT guerwei efficacyofperineuraldexamethasonewithropivacaineinthoracicparavertebralblockforpostoperativeanalgesiainelectivethoracotomyarandomizeddoubleblindplacebocontrolledtrial