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Combined use of CDK4/6 and mTOR inhibitors induce synergistic growth arrest of diffuse intrinsic pontine glioma cells via mutual downregulation of mTORC1 activity

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a lethal type of pediatric brain tumor that is resistant to conventional chemotherapies. Palbociclib is a putative novel DIPG treatment that restricts the proliferation of rapidly dividing cancer cells via selective inhibition of cyclin-dependen...

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Detalles Bibliográficos
Autores principales:	Asby, Daniel J, Killick-Cole, Clare L, Boulter, Lisa J, Singleton, William GB, Asby, Claire A, Wyatt, Marcella J, Barua, Neil U, Bienemann, Alison S, Gill, Steven S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140749/ https://www.ncbi.nlm.nih.gov/pubmed/30254491 http://dx.doi.org/10.2147/CMAR.S167095

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