Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity

Gain-of-function mutations in phosphoinositide 3-kinase p110δ (PI3Kδ) result in a human primary immunodeficiency characterized by lymphoproliferation, respiratory infections and inefficient vaccine responses. However, what promotes these immune disturbances at the cellular and molecular level remain...

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Detalles Bibliográficos
Autores principales: Preite, Silvia, Cannons, Jennifer L., Radtke, Andrea J., Vujkovic-Cvijin, Ivan, Gomez-Rodriguez, Julio, Volpi, Stefano, Huang, Bonnie, Cheng, Jun, Collins, Nicholas, Reilley, Julie, Handon, Robin, Dobbs, Kerry, Huq, Lutfi, Raman, Indu, Zhu, Chengsong, Li, Quan-Zhen, Li, Ming O., Pittaluga, Stefania, Uzel, Gulbu, Notarangelo, Luigi D., Belkaid, Yasmine, Germain, Ronald N., Schwartzberg, Pamela L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140795/
https://www.ncbi.nlm.nih.gov/pubmed/30127432
http://dx.doi.org/10.1038/s41590-018-0182-3

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