Exploratory Profiling of Urine MicroRNAs in the dy(2J)/dy(2J) Mouse Model of LAMA2-CMD: Relation to Disease Progression

Circulating microRNAs (miRNAs) are being considered as non-invasive biomarkers for disease progression and clinical trials. Congenital muscular dystrophy with deficiency of laminin α2 chain (LAMA2-CMD) is a very severe form of muscular dystrophy, for which no treatment is available. In order to iden...

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Autores principales: Moreira Soares Oliveira, Bernardo, Gawlik, Kinga I, Durbeej, Madeleine, Holmberg, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Animal Models
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140833/
https://www.ncbi.nlm.nih.gov/pubmed/30430039
http://dx.doi.org/10.1371/currents.md.d0c203c018bc024f2f4c9791ecb05f88
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author Moreira Soares Oliveira, Bernardo
Gawlik, Kinga I
Durbeej, Madeleine
Holmberg, Johan
author_facet Moreira Soares Oliveira, Bernardo
Gawlik, Kinga I
Durbeej, Madeleine
Holmberg, Johan
author_sort Moreira Soares Oliveira, Bernardo
collection PubMed
description Circulating microRNAs (miRNAs) are being considered as non-invasive biomarkers for disease progression and clinical trials. Congenital muscular dystrophy with deficiency of laminin α2 chain (LAMA2-CMD) is a very severe form of muscular dystrophy, for which no treatment is available. In order to identify LAMA2-CMD biomarkers we have profiled miRNAs in urine from the dy(2J)/dy(2J) mouse model of LAMA2-CMD at three distinct time points (representing asymptomatic, initial and established disease). We demonstrate that unique groups of miRNAs are differentially expressed at each time point. We suggest that urine miRNAs can be sensitive biomarkers for different stages of LAMA2-CMD.
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spelling pubmed-61408332018-11-13 Exploratory Profiling of Urine MicroRNAs in the dy(2J)/dy(2J) Mouse Model of LAMA2-CMD: Relation to Disease Progression Moreira Soares Oliveira, Bernardo Gawlik, Kinga I Durbeej, Madeleine Holmberg, Johan PLoS Curr Animal Models Circulating microRNAs (miRNAs) are being considered as non-invasive biomarkers for disease progression and clinical trials. Congenital muscular dystrophy with deficiency of laminin α2 chain (LAMA2-CMD) is a very severe form of muscular dystrophy, for which no treatment is available. In order to identify LAMA2-CMD biomarkers we have profiled miRNAs in urine from the dy(2J)/dy(2J) mouse model of LAMA2-CMD at three distinct time points (representing asymptomatic, initial and established disease). We demonstrate that unique groups of miRNAs are differentially expressed at each time point. We suggest that urine miRNAs can be sensitive biomarkers for different stages of LAMA2-CMD. Public Library of Science 2018-08-27 /pmc/articles/PMC6140833/ /pubmed/30430039 http://dx.doi.org/10.1371/currents.md.d0c203c018bc024f2f4c9791ecb05f88 Text en © 2018 Moreira Soares Oliveira, Gawlik, Durbeej, Holmberg, et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Animal Models
Moreira Soares Oliveira, Bernardo
Gawlik, Kinga I
Durbeej, Madeleine
Holmberg, Johan
Exploratory Profiling of Urine MicroRNAs in the dy(2J)/dy(2J) Mouse Model of LAMA2-CMD: Relation to Disease Progression
title Exploratory Profiling of Urine MicroRNAs in the dy(2J)/dy(2J) Mouse Model of LAMA2-CMD: Relation to Disease Progression
title_full Exploratory Profiling of Urine MicroRNAs in the dy(2J)/dy(2J) Mouse Model of LAMA2-CMD: Relation to Disease Progression
title_fullStr Exploratory Profiling of Urine MicroRNAs in the dy(2J)/dy(2J) Mouse Model of LAMA2-CMD: Relation to Disease Progression
title_full_unstemmed Exploratory Profiling of Urine MicroRNAs in the dy(2J)/dy(2J) Mouse Model of LAMA2-CMD: Relation to Disease Progression
title_short Exploratory Profiling of Urine MicroRNAs in the dy(2J)/dy(2J) Mouse Model of LAMA2-CMD: Relation to Disease Progression
title_sort exploratory profiling of urine micrornas in the dy(2j)/dy(2j) mouse model of lama2-cmd: relation to disease progression
topic Animal Models
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140833/
https://www.ncbi.nlm.nih.gov/pubmed/30430039
http://dx.doi.org/10.1371/currents.md.d0c203c018bc024f2f4c9791ecb05f88
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