A novel microfluidic liposomal formulation for the delivery of the SN-38 camptothecin: characterization and in vitro assessment of its cytotoxic effect on two tumor cell lines

PURPOSE: Irinotecan (CPT-11) and SN-38 – its active metabolite – are alkaloid-derived topoisomerase I interactive compounds widely used in various cancer therapy protocols. To solve the problems associated with the instability of their lactone ring at physiological pH and with the extreme insolubili...

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Detalles Bibliográficos
Autores principales: Casadó, Ana, Sagristá, M Lluïsa, Mora, Margarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141119/
https://www.ncbi.nlm.nih.gov/pubmed/30254436
http://dx.doi.org/10.2147/IJN.S166219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141119/
https://www.ncbi.nlm.nih.gov/pubmed/30254436
http://dx.doi.org/10.2147/IJN.S166219

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