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Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells
Following CNS demyelination, oligodendrocyte progenitor cells (OPCs) are able to differentiate into either remyelinating oligodendrocytes (OLs) or remyelinating Schwann cells (SCs). However, the signals that determine which type of remyelinating cell is generated and the underlying mechanisms involv...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141235/ https://www.ncbi.nlm.nih.gov/pubmed/30222103 http://dx.doi.org/10.7554/eLife.30325 |
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author | Ulanska-Poutanen, Justyna Mieczkowski, Jakub Zhao, Chao Konarzewska, Katarzyna Kaza, Beata Pohl, Hartmut BF Bugajski, Lukasz Kaminska, Bozena Franklin, Robin JM Zawadzka, Malgorzata |
author_facet | Ulanska-Poutanen, Justyna Mieczkowski, Jakub Zhao, Chao Konarzewska, Katarzyna Kaza, Beata Pohl, Hartmut BF Bugajski, Lukasz Kaminska, Bozena Franklin, Robin JM Zawadzka, Malgorzata |
author_sort | Ulanska-Poutanen, Justyna |
collection | PubMed |
description | Following CNS demyelination, oligodendrocyte progenitor cells (OPCs) are able to differentiate into either remyelinating oligodendrocytes (OLs) or remyelinating Schwann cells (SCs). However, the signals that determine which type of remyelinating cell is generated and the underlying mechanisms involved have not been identified. Here, we show that distinctive microenvironments created in discrete niches within demyelinated white matter determine fate decisions of adult OPCs. By comparative transcriptome profiling we demonstrate that an ectopic, injury-induced perivascular niche is enriched with secreted ligands of the BMP and Wnt signalling pathways, produced by activated OPCs and endothelium, whereas reactive astrocyte within non-vascular area express the dual BMP/Wnt antagonist Sostdc1. The balance of BMP/Wnt signalling network is instructive for OPCs to undertake fate decision shortly after their activation: disruption of the OPCs homeostasis during demyelination results in BMP4 upregulation, which, in the absence of Socstdc1, favours SCs differentiation. |
format | Online Article Text |
id | pubmed-6141235 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-61412352018-09-20 Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells Ulanska-Poutanen, Justyna Mieczkowski, Jakub Zhao, Chao Konarzewska, Katarzyna Kaza, Beata Pohl, Hartmut BF Bugajski, Lukasz Kaminska, Bozena Franklin, Robin JM Zawadzka, Malgorzata eLife Neuroscience Following CNS demyelination, oligodendrocyte progenitor cells (OPCs) are able to differentiate into either remyelinating oligodendrocytes (OLs) or remyelinating Schwann cells (SCs). However, the signals that determine which type of remyelinating cell is generated and the underlying mechanisms involved have not been identified. Here, we show that distinctive microenvironments created in discrete niches within demyelinated white matter determine fate decisions of adult OPCs. By comparative transcriptome profiling we demonstrate that an ectopic, injury-induced perivascular niche is enriched with secreted ligands of the BMP and Wnt signalling pathways, produced by activated OPCs and endothelium, whereas reactive astrocyte within non-vascular area express the dual BMP/Wnt antagonist Sostdc1. The balance of BMP/Wnt signalling network is instructive for OPCs to undertake fate decision shortly after their activation: disruption of the OPCs homeostasis during demyelination results in BMP4 upregulation, which, in the absence of Socstdc1, favours SCs differentiation. eLife Sciences Publications, Ltd 2018-09-17 /pmc/articles/PMC6141235/ /pubmed/30222103 http://dx.doi.org/10.7554/eLife.30325 Text en © 2018, Ulanska-Poutanen et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Ulanska-Poutanen, Justyna Mieczkowski, Jakub Zhao, Chao Konarzewska, Katarzyna Kaza, Beata Pohl, Hartmut BF Bugajski, Lukasz Kaminska, Bozena Franklin, Robin JM Zawadzka, Malgorzata Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells |
title | Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells |
title_full | Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells |
title_fullStr | Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells |
title_full_unstemmed | Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells |
title_short | Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells |
title_sort | injury-induced perivascular niche supports alternative differentiation of adult rodent cns progenitor cells |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141235/ https://www.ncbi.nlm.nih.gov/pubmed/30222103 http://dx.doi.org/10.7554/eLife.30325 |
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