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Cholelithiasis in Thalassemia Major Patients: A Report from the South-East of Iran

Background: Cholelithiasis and its predisposing factors are less characterized in thalassemia syndromes. In the present study, we assessed the prevalence of gallstones and related-risk factors among thalassemia major (TM) patients in south-east of Iran. Materials and Methods: The patients were recru...

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Autores principales: Shahramian, Iraj, Behzadmehr, Razieh, Afshari, Mahdi, Allahdadi, Atefeh, Delaramnasab, Mojtaba, Bazi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141427/
https://www.ncbi.nlm.nih.gov/pubmed/30233773
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author Shahramian, Iraj
Behzadmehr, Razieh
Afshari, Mahdi
Allahdadi, Atefeh
Delaramnasab, Mojtaba
Bazi, Ali
author_facet Shahramian, Iraj
Behzadmehr, Razieh
Afshari, Mahdi
Allahdadi, Atefeh
Delaramnasab, Mojtaba
Bazi, Ali
author_sort Shahramian, Iraj
collection PubMed
description Background: Cholelithiasis and its predisposing factors are less characterized in thalassemia syndromes. In the present study, we assessed the prevalence of gallstones and related-risk factors among thalassemia major (TM) patients in south-east of Iran. Materials and Methods: The patients were recruited form a single center in Zabol city, south-east of Iran. Demographic and clinical information were retrieved from medical histories. Abdominal ultrasonography was performed to scrutinize gallstones and organ dimensions of liver, spleen, gallbladder and kidney. Results: The study participants (n=127) consisted of 50 (39.4%) males and 77 (60.6%) females. The mean age of the patients was 15.2±7.9 years. Cholelithiasis was observed in 11 (8.7%) patients. Cholelithiasis was significantly associated with age (P=0.002) and splenectomy (P=0.001). The patients with cholelithiasis received a significantly higher blood volume than patients without cholelithiasis (546±108.7 ml and 425.1±134.7 ml, respectively, P=0.007). There were significant differences between cholelithiasis and non- cholelithiasis TM patients regarding the length of right and left liver lobes (P=0.001), as well as the length of gallbladder (P=0.006). Ferritin level was not associated with cholelithiasis in our patients. In multivariate analysis, age older than 15 (OR=10.4, 95% CI: 1.2-86.3, P=0.02) and 30 years old (OR=42.6, 95% CI: 2.9-613, P=0.006), and splenectomy (OR=8.7, 95% CI: 2.1-35.4, P=0.002) were significant risk factors for cholelithiasis. Conclusion: Cholelithiasis is a relatively common complication among TM patients in our region. The most prominent risk factors of cholelithiasis were advanced age, splenectomy and large-volume blood transfusion.
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spelling pubmed-61414272018-09-19 Cholelithiasis in Thalassemia Major Patients: A Report from the South-East of Iran Shahramian, Iraj Behzadmehr, Razieh Afshari, Mahdi Allahdadi, Atefeh Delaramnasab, Mojtaba Bazi, Ali Int J Hematol Oncol Stem Cell Res Original Article Background: Cholelithiasis and its predisposing factors are less characterized in thalassemia syndromes. In the present study, we assessed the prevalence of gallstones and related-risk factors among thalassemia major (TM) patients in south-east of Iran. Materials and Methods: The patients were recruited form a single center in Zabol city, south-east of Iran. Demographic and clinical information were retrieved from medical histories. Abdominal ultrasonography was performed to scrutinize gallstones and organ dimensions of liver, spleen, gallbladder and kidney. Results: The study participants (n=127) consisted of 50 (39.4%) males and 77 (60.6%) females. The mean age of the patients was 15.2±7.9 years. Cholelithiasis was observed in 11 (8.7%) patients. Cholelithiasis was significantly associated with age (P=0.002) and splenectomy (P=0.001). The patients with cholelithiasis received a significantly higher blood volume than patients without cholelithiasis (546±108.7 ml and 425.1±134.7 ml, respectively, P=0.007). There were significant differences between cholelithiasis and non- cholelithiasis TM patients regarding the length of right and left liver lobes (P=0.001), as well as the length of gallbladder (P=0.006). Ferritin level was not associated with cholelithiasis in our patients. In multivariate analysis, age older than 15 (OR=10.4, 95% CI: 1.2-86.3, P=0.02) and 30 years old (OR=42.6, 95% CI: 2.9-613, P=0.006), and splenectomy (OR=8.7, 95% CI: 2.1-35.4, P=0.002) were significant risk factors for cholelithiasis. Conclusion: Cholelithiasis is a relatively common complication among TM patients in our region. The most prominent risk factors of cholelithiasis were advanced age, splenectomy and large-volume blood transfusion. Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2018-04-01 /pmc/articles/PMC6141427/ /pubmed/30233773 Text en Copyright : © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shahramian, Iraj
Behzadmehr, Razieh
Afshari, Mahdi
Allahdadi, Atefeh
Delaramnasab, Mojtaba
Bazi, Ali
Cholelithiasis in Thalassemia Major Patients: A Report from the South-East of Iran
title Cholelithiasis in Thalassemia Major Patients: A Report from the South-East of Iran
title_full Cholelithiasis in Thalassemia Major Patients: A Report from the South-East of Iran
title_fullStr Cholelithiasis in Thalassemia Major Patients: A Report from the South-East of Iran
title_full_unstemmed Cholelithiasis in Thalassemia Major Patients: A Report from the South-East of Iran
title_short Cholelithiasis in Thalassemia Major Patients: A Report from the South-East of Iran
title_sort cholelithiasis in thalassemia major patients: a report from the south-east of iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141427/
https://www.ncbi.nlm.nih.gov/pubmed/30233773
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