Chaperonin 60 sustains osteoblast autophagy and counteracts glucocorticoid aggravation of osteoporosis by chaperoning RPTOR

Glucocorticoid excess medication interrupts osteoblast homeostasis and exacerbates bone mass and microstructure loss ramping up the pathogenesis of osteoporotic disorders. Heat shock protein 60 (HSP60) is found to maintain protein function within cellular microenvironment upon encountering detriment...

Descripción completa

Detalles Bibliográficos
Autores principales: Lian, Wei-Shiung, Ko, Jih-Yang, Chen, Yu-Shan, Ke, Huei-Ching, Wu, Shin-Long, Kuo, Chung-Wen, Wang, Feng-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141469/
https://www.ncbi.nlm.nih.gov/pubmed/30224697
http://dx.doi.org/10.1038/s41419-018-0970-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141469/
https://www.ncbi.nlm.nih.gov/pubmed/30224697
http://dx.doi.org/10.1038/s41419-018-0970-6

Ejemplares similares