Enhanced Sensitivity of Patient-Derived Pediatric High-Grade Brain Tumor Xenografts to Oncolytic HSV-1 Virotherapy Correlates with Nectin-1 Expression

Pediatric high-grade brain tumors and adult glioblastoma are associated with significant morbidity and mortality. Oncolytic herpes simplex virus-1 (oHSV) is a promising approach to target brain tumors; oHSV G207 and M032 (encodes human interleukin-12) are currently in phase I clinical trials in chil...

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Detalles Bibliográficos
Autores principales: Friedman, Gregory K., Bernstock, Joshua D., Chen, Dongquan, Nan, Li, Moore, Blake P., Kelly, Virginia M., Youngblood, Samantha L., Langford, Catherine P., Han, Xiaosi, Ring, Eric K., Beierle, Elizabeth A., Gillespie, G. Yancey, Markert, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141470/
https://www.ncbi.nlm.nih.gov/pubmed/30224769
http://dx.doi.org/10.1038/s41598-018-32353-x

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