Cargando…

Development of a novel Hsp90 inhibitor NCT-50 as a potential anticancer agent for the treatment of non-small cell lung cancer

Despite the development of advanced therapeutic regimens such as molecular targeted therapy and immunotherapy, the 5-year survival of patients with lung cancer is still less than 20%, suggesting the need to develop additional treatment strategies. The molecular chaperone heat shock protein 90 (Hsp90...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hyun, Seung Yeob, Le, Huong Thuy, Nguyen, Cong-Truong, Yong, Young-Sik, Boo, Hye-Jin, Lee, Ho Jin, Lee, Ji-Sun, Min, Hye-Young, Ann, Jihyae, Chen, Jie, Park, Hyun-Ju, Lee, Jeewoo, Lee, Ho-Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141536/ https://www.ncbi.nlm.nih.gov/pubmed/30224681 http://dx.doi.org/10.1038/s41598-018-32196-6

Ejemplares similares

A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects
por: Lee, Ho Jin, et al.
Publicado: (2022)

The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells
por: Park, Soeun, et al.
Publicado: (2021)

A novel HSP90 inhibitor targeting the C-terminal domain attenuates trastuzumab resistance in HER2-positive breast cancer
por: Park, Jung Min, et al.
Publicado: (2020)

Potent Anticancer Effect of the Natural Steroidal Saponin Gracillin Is Produced by Inhibiting Glycolysis and Oxidative Phosphorylation-Mediated Bioenergetics
por: Min, Hye-Young, et al.
Publicado: (2020)

An Aminopropyl Carbazole Derivative Induces Neurogenesis by Increasing Final Cell Division in Neural Stem Cells
por: Shin, Jae-Yeon, et al.
Publicado: (2015)

Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancer
por: Ahn, Ji-Young, et al.
Publicado: (2015)

A novel HSP90 inhibitor SL-145 suppresses metastatic triple-negative breast cancer without triggering the heat shock response
por: Kim, Ji Young, et al.
Publicado: (2022)

Ninjurin1 drives lung tumor formation and progression by potentiating Wnt/β-Catenin signaling through Frizzled2-LRP6 assembly
por: Hyun, Seung Yeob, et al.
Publicado: (2022)

Functional Group-Dependent Induction of Astrocytogenesis and Neurogenesis by Flavone Derivatives
por: Lee, Ha-Rim, et al.
Publicado: (2019)

Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity
por: Lee, Ho Jin, et al.
Publicado: (2018)

Correction: Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity
por: Lee, Ho Jin, et al.
Publicado: (2023)

Molecular targeted therapy for anticancer treatment
por: Min, Hye-Young, et al.
Publicado: (2022)

Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1
por: Park, Hye-Kyung, et al.
Publicado: (2020)

Smoking-associated lung cancer prevention by blockade of the beta-adrenergic receptor-mediated insulin-like growth factor receptor activation
por: Min, Hye-Young, et al.
Publicado: (2016)

Insulin-Like Growth Factor Binding Protein-3 Exerts Its Anti-Metastatic Effect in Aerodigestive Tract Cancers by Disrupting the Protein Stability of Vimentin
por: Le, Huong Thuy, et al.
Publicado: (2021)

Discovery of Novel Dual Adenosine A(2A) and A(1) Receptor Antagonists with 1H-Pyrazolo[3,4-d]pyrimidin-6-amine Core Scaffold as Anti-Parkinson’s Disease Agents
por: Jung, Juyoung, et al.
Publicado: (2022)

Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level
por: Pearce, Larry V., et al.
Publicado: (2019)

Evodiamine inhibits both stem cell and non-stem-cell populations in human cancer cells by targeting heat shock protein 70
por: Hyun, Seung Yeob, et al.
Publicado: (2021)

RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse
por: Cho, Jaebeom, et al.
Publicado: (2023)

HSP90 inhibitor 17-DMAG exerts anticancer effects against gastric cancer cells principally by altering oxidant-antioxidant balance
por: Kim, Jeong Goo, et al.
Publicado: (2017)

Structural Basis for Design of New Purine-Based Inhibitors Targeting the Hydrophobic Binding Pocket of Hsp90
por: Shin, Sang Chul, et al.
Publicado: (2020)

Stability of the Human Hsp90-p50(Cdc37) Chaperone Complex against Nucleotides and Hsp90 Inhibitors, and the Influence of Phosphorylation by Casein Kinase 2
por: Olesen, Sanne H., et al.
Publicado: (2015)

Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage
por: Park, Sangkyu, et al.
Publicado: (2019)

Ophthalmologic manifestations in patients with inflammatory bowel disease
por: Lee, Hye Jin, et al.
Publicado: (2017)

The natural compound gracillin exerts potent antitumor activity by targeting mitochondrial complex II
por: Min, Hye-Young, et al.
Publicado: (2019)

Bruceantin targets HSP90 to overcome resistance to hormone therapy in castration-resistant prostate cancer
por: Moon, Sue Jin, et al.
Publicado: (2021)

Heterotypic cell-in-cell structures between cancer and NK cells are associated with enhanced anticancer drug resistance
por: Choe, Yun-Jeong, et al.
Publicado: (2022)

Targeting the MYC Oncogene in Burkitt Lymphoma through HSP90 Inhibition
por: Poole, Candace J., et al.
Publicado: (2018)

Boosting the effects of hyperthermia-based anticancer treatments by HSP90 inhibition
por: Vriend, Lianne E.M., et al.
Publicado: (2017)

Heterocyclic Compounds as Hsp90 Inhibitors: A Perspective on Anticancer Applications
por: Ardestani, Mina, et al.
Publicado: (2022)

LJ-2698, an Adenosine A(3) Receptor Antagonist, Alleviates Elastase-Induced Pulmonary Emphysema in Mice
por: Boo, Hye-Jin, et al.
Publicado: (2020)

Enhancing viability and angiogenic efficacy of mesenchymal stem cells via HSP90α and HSP27 regulation based on ROS stimulation for wound healing
por: Seo, Inwoo, et al.
Publicado: (2023)

Association of Work Patterns and Periodontitis Prevalence in Korean Adults Aged 50 Years or Older: A Nationwide Representative Study
por: Ra, Young Jin, et al.
Publicado: (2020)

Nonsteroidal Anti-inflammatory Drugs Sensitize CD44-Overexpressing Cancer Cells to Hsp90 Inhibitor Through Autophagy Activation
por: Moon, Hyun-Jung, et al.
Publicado: (2019)

Hsp40s Specify Functions of Hsp104 and Hsp90 Protein Chaperone Machines
por: Reidy, Michael, et al.
Publicado: (2014)

Liquid-type plasma-controlled in situ crosslinking of silk-alginate injectable gel displayed better bioactivities and mechanical properties
por: Kim, Sungryeal, et al.
Publicado: (2022)

The novel IGF-IR/Akt–dependent anticancer activities of glucosamine
por: Song, Ki-Hoon, et al.
Publicado: (2014)

The tobacco-specific carcinogen NNK induces pulmonary tumorigenesis via nAChR/Src/STAT3-mediated activation of the renin-angiotensin system and IGF-1R signaling
por: Boo, Hye-Jin, et al.
Publicado: (2023)

Essential role of insulin-like growth factor 2 in resistance to histone deacetylase inhibitors
por: Lee, Su-Chan, et al.
Publicado: (2016)

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation
por: Kijima, Toshiki, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_c8psgr5gj4lc3tjf6pv93agt2h