Assembly of Plasmonic and Magnetic Nanoparticles with Fluorescent Silica Shell Layer for Tri-functional SERS-Magnetic-Fluorescence Probes and Its Bioapplications

In this study, we report on the fabrication of multilayered tri-functional magnetic-SERS-fluorescence nanoprobes (MF-SERS particles) containing clustered superparamagnetic Fe(3)O(4) nanoparticles (NPs), silver NPs, and a fluorescent silica layer. The MF-SERS particles exhibited strong SERS signals f...

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Detalles Bibliográficos
Autores principales: Kim, Hyung-Mo, Kim, Dong-Min, Jeong, Cheolhwan, Park, So Yeon, Cha, Myeong Geun, Ha, Yuna, Jang, Dahye, Kyeong, San, Pham, Xuan-Hung, Hahm, Eunil, Lee, Sang Hun, Jeong, Dae Hong, Lee, Yoon-Sik, Kim, Dong-Eun, Jun, Bong-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141549/
https://www.ncbi.nlm.nih.gov/pubmed/30224683
http://dx.doi.org/10.1038/s41598-018-32044-7
Descripción
Sumario:In this study, we report on the fabrication of multilayered tri-functional magnetic-SERS-fluorescence nanoprobes (MF-SERS particles) containing clustered superparamagnetic Fe(3)O(4) nanoparticles (NPs), silver NPs, and a fluorescent silica layer. The MF-SERS particles exhibited strong SERS signals from the silver NPs as well as both superparamagnetism and fluorescence. MF–SERS particles were uptaken by cells, allowing successful separation using an external magnetic field. SERS and fluorescence signals could be detected from the NP-containing cells, and CD44 antibody-conjugated MF-SERS particles selectively targeted MDA-MB-231 cells. Based on these properties, MF-SERS particles proved to be a useful nanoprobe for multiplex detection and separation of cancer cells.

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