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Sarcolab pilot study into skeletal muscle’s adaptation to long-term spaceflight
Spaceflight causes muscle wasting. The Sarcolab pilot study investigated two astronauts with regards to plantar flexor muscle size, architecture, and function, and to the underlying molecular adaptations in order to further the understanding of muscular responses to spaceflight and exercise counterm...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141586/ https://www.ncbi.nlm.nih.gov/pubmed/30246141 http://dx.doi.org/10.1038/s41526-018-0052-1 |
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author | Rittweger, Jörn Albracht, Kirsten Flück, Martin Ruoss, Severin Brocca, Lorenza Longa, Emanuela Moriggi, Manuela Seynnes, Olivier Di Giulio, Irene Tenori, Leonardo Vignoli, Alessia Capri, Miriam Gelfi, Cecilia Luchinat, Claudio Franceschi, Claudio Bottinelli, Roberto Cerretelli, Paolo Narici, Marco |
author_facet | Rittweger, Jörn Albracht, Kirsten Flück, Martin Ruoss, Severin Brocca, Lorenza Longa, Emanuela Moriggi, Manuela Seynnes, Olivier Di Giulio, Irene Tenori, Leonardo Vignoli, Alessia Capri, Miriam Gelfi, Cecilia Luchinat, Claudio Franceschi, Claudio Bottinelli, Roberto Cerretelli, Paolo Narici, Marco |
author_sort | Rittweger, Jörn |
collection | PubMed |
description | Spaceflight causes muscle wasting. The Sarcolab pilot study investigated two astronauts with regards to plantar flexor muscle size, architecture, and function, and to the underlying molecular adaptations in order to further the understanding of muscular responses to spaceflight and exercise countermeasures. Two crew members (A and B) spent 6 months in space. Crew member A trained less vigorously than B. Postflight, A showed substantial decrements in plantar flexor volume, muscle architecture, in strength and in fiber contractility, which was strongly mitigated in B. The difference between these crew members closely reflected FAK-Y397 abundance, a molecular marker of muscle’s loading history. Moreover, crew member A showed downregulation of contractile proteins and enzymes of anaerobic metabolism, as well as of systemic markers of energy and protein metabolism. However, both crew members exhibited decrements in muscular aerobic metabolism and phosphate high energy transfer. We conclude that countermeasures can be effective, particularly when resistive forces are of sufficient magnitude. However, to fully prevent space-related muscular deterioration, intersubject variability must be understood, and intensive exercise countermeasures programs seem mandatory. Finally, proteomic and metabolomic analyses suggest that exercise benefits in space may go beyond mere maintenance of muscle mass, but rather extend to the level of organismic metabolism. |
format | Online Article Text |
id | pubmed-6141586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61415862018-09-21 Sarcolab pilot study into skeletal muscle’s adaptation to long-term spaceflight Rittweger, Jörn Albracht, Kirsten Flück, Martin Ruoss, Severin Brocca, Lorenza Longa, Emanuela Moriggi, Manuela Seynnes, Olivier Di Giulio, Irene Tenori, Leonardo Vignoli, Alessia Capri, Miriam Gelfi, Cecilia Luchinat, Claudio Franceschi, Claudio Bottinelli, Roberto Cerretelli, Paolo Narici, Marco NPJ Microgravity Article Spaceflight causes muscle wasting. The Sarcolab pilot study investigated two astronauts with regards to plantar flexor muscle size, architecture, and function, and to the underlying molecular adaptations in order to further the understanding of muscular responses to spaceflight and exercise countermeasures. Two crew members (A and B) spent 6 months in space. Crew member A trained less vigorously than B. Postflight, A showed substantial decrements in plantar flexor volume, muscle architecture, in strength and in fiber contractility, which was strongly mitigated in B. The difference between these crew members closely reflected FAK-Y397 abundance, a molecular marker of muscle’s loading history. Moreover, crew member A showed downregulation of contractile proteins and enzymes of anaerobic metabolism, as well as of systemic markers of energy and protein metabolism. However, both crew members exhibited decrements in muscular aerobic metabolism and phosphate high energy transfer. We conclude that countermeasures can be effective, particularly when resistive forces are of sufficient magnitude. However, to fully prevent space-related muscular deterioration, intersubject variability must be understood, and intensive exercise countermeasures programs seem mandatory. Finally, proteomic and metabolomic analyses suggest that exercise benefits in space may go beyond mere maintenance of muscle mass, but rather extend to the level of organismic metabolism. Nature Publishing Group UK 2018-09-17 /pmc/articles/PMC6141586/ /pubmed/30246141 http://dx.doi.org/10.1038/s41526-018-0052-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Rittweger, Jörn Albracht, Kirsten Flück, Martin Ruoss, Severin Brocca, Lorenza Longa, Emanuela Moriggi, Manuela Seynnes, Olivier Di Giulio, Irene Tenori, Leonardo Vignoli, Alessia Capri, Miriam Gelfi, Cecilia Luchinat, Claudio Franceschi, Claudio Bottinelli, Roberto Cerretelli, Paolo Narici, Marco Sarcolab pilot study into skeletal muscle’s adaptation to long-term spaceflight |
title | Sarcolab pilot study into skeletal muscle’s adaptation to long-term spaceflight |
title_full | Sarcolab pilot study into skeletal muscle’s adaptation to long-term spaceflight |
title_fullStr | Sarcolab pilot study into skeletal muscle’s adaptation to long-term spaceflight |
title_full_unstemmed | Sarcolab pilot study into skeletal muscle’s adaptation to long-term spaceflight |
title_short | Sarcolab pilot study into skeletal muscle’s adaptation to long-term spaceflight |
title_sort | sarcolab pilot study into skeletal muscle’s adaptation to long-term spaceflight |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141586/ https://www.ncbi.nlm.nih.gov/pubmed/30246141 http://dx.doi.org/10.1038/s41526-018-0052-1 |
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