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Inhibition of HBV Expression in HBV Transgenic Mice Using AAV-Delivered CRISPR-SaCas9

The chronic production of hepatitis B viral (HBV) antigens could cause inflammation and necrosis, leading to elevation of liver enzymes from necrotic hepatocytes, hepatitis, cirrhosis, hepatocellular carcinoma, and liver failure. However, no current treatment is capable of significantly reducing HBs...

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Detalles Bibliográficos
Autores principales:	Li, Hao, Sheng, Chunyu, Liu, Hongbo, Wang, Shan, Zhao, Jiangyun, Yang, Lang, Jia, Leili, Li, Peng, Wang, Ligui, Xie, Jing, Xu, Dongping, Sun, Yansong, Qiu, Shaofu, Song, Hongbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141737/ https://www.ncbi.nlm.nih.gov/pubmed/30254645 http://dx.doi.org/10.3389/fimmu.2018.02080

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