RNA Interference as a Prospective Tool for the Control of Human Viral Infections

RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived from viral genome or its replicative intermediates, is a natural antiviral defense in plants, fungi, and invertebrates. Whether RNAi naturally protects humans from viral invasion is still a matter of debate. Nevert...

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Detalles Bibliográficos
Autores principales: Levanova, Alesia, Poranen, Minna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141738/
https://www.ncbi.nlm.nih.gov/pubmed/30254624
http://dx.doi.org/10.3389/fmicb.2018.02151
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author Levanova, Alesia
Poranen, Minna M.
author_facet Levanova, Alesia
Poranen, Minna M.
author_sort Levanova, Alesia
collection PubMed
description RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived from viral genome or its replicative intermediates, is a natural antiviral defense in plants, fungi, and invertebrates. Whether RNAi naturally protects humans from viral invasion is still a matter of debate. Nevertheless, exogenous siRNAs are able to halt viral infection in mammals. The current review critically evaluates the production of antiviral siRNAs, delivery techniques to the infection sites, as well as provides an overview of antiviral siRNAs in clinical trials.
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spelling pubmed-61417382018-09-25 RNA Interference as a Prospective Tool for the Control of Human Viral Infections Levanova, Alesia Poranen, Minna M. Front Microbiol Microbiology RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived from viral genome or its replicative intermediates, is a natural antiviral defense in plants, fungi, and invertebrates. Whether RNAi naturally protects humans from viral invasion is still a matter of debate. Nevertheless, exogenous siRNAs are able to halt viral infection in mammals. The current review critically evaluates the production of antiviral siRNAs, delivery techniques to the infection sites, as well as provides an overview of antiviral siRNAs in clinical trials. Frontiers Media S.A. 2018-09-11 /pmc/articles/PMC6141738/ /pubmed/30254624 http://dx.doi.org/10.3389/fmicb.2018.02151 Text en Copyright © 2018 Levanova and Poranen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Levanova, Alesia
Poranen, Minna M.
RNA Interference as a Prospective Tool for the Control of Human Viral Infections
title RNA Interference as a Prospective Tool for the Control of Human Viral Infections
title_full RNA Interference as a Prospective Tool for the Control of Human Viral Infections
title_fullStr RNA Interference as a Prospective Tool for the Control of Human Viral Infections
title_full_unstemmed RNA Interference as a Prospective Tool for the Control of Human Viral Infections
title_short RNA Interference as a Prospective Tool for the Control of Human Viral Infections
title_sort rna interference as a prospective tool for the control of human viral infections
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141738/
https://www.ncbi.nlm.nih.gov/pubmed/30254624
http://dx.doi.org/10.3389/fmicb.2018.02151
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