SERPINB3 Delays Glomerulonephritis and Attenuates the Lupus-Like Disease in Lupus Murine Models by Inducing a More Tolerogenic Immune Phenotype

Objective: To explore the effects of SERPINB3 administration in murine lupus models with a focus on lupus-like nephritis. Methods: 40 NZB/W F1 mice were subdivided into 4 groups and intraperitoneally injected with recombinant SERPINB3 (7.5 μg/0.1 mL or 15 μg/0.1 mL) or PBS (0.1 mL) before (group 1 a...

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Detalles Bibliográficos
Autores principales: Gatto, Mariele, Luisetto, Roberto, Ghirardello, Anna, Cavicchioli, Laura, Codolo, Gaia, Biasiolo, Alessandra, Maggioni, Giuseppe, Saccon, Francesca, Beggio, Marianna, Cappon, Andrea, Venturini, Roberta, Pontisso, Patrizia, Doria, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141748/
https://www.ncbi.nlm.nih.gov/pubmed/30254646
http://dx.doi.org/10.3389/fimmu.2018.02081

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