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Hydrogel-forming microneedles enhance transdermal delivery of metformin hydrochloride

We investigated, for the first time, the potential for a hydrogel-forming microneedle (MN) patch to deliver the high-dose drug metformin HCl transdermally in a sustained manner. This may minimize some gastrointestinal side effects and small intestine absorption variations associated with oral delive...

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Detalles Bibliográficos
Autores principales:	Migdadi, Eman M., Courtenay, Aaron J., Tekko, Ismaiel A., McCrudden, Maelíosa T.C., Kearney, Mary-Carmel, McAlister, Emma, McCarthy, Helen O., Donnelly, Ryan F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Publishers 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141810/ https://www.ncbi.nlm.nih.gov/pubmed/29990526 http://dx.doi.org/10.1016/j.jconrel.2018.07.009

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