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Assessment of image quality of a radiotherapy-specific hardware solution for PET/MRI in head and neck cancer patients
BACKGROUND AND PURPOSE: Functional PET/MRI has great potential to improve radiotherapy planning (RTP). However, data integration requires imaging with radiotherapy-specific patient positioning. Here, we investigated the feasibility and image quality of radiotherapy-customized PET/MRI in head-and-nec...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Scientific Publishers
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141811/ https://www.ncbi.nlm.nih.gov/pubmed/29747873 http://dx.doi.org/10.1016/j.radonc.2018.04.018 |
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author | Winter, René M. Leibfarth, Sara Schmidt, Holger Zwirner, Kerstin Mönnich, David Welz, Stefan Schwenzer, Nina F. la Fougère, Christian Nikolaou, Konstantin Gatidis, Sergios Zips, Daniel Thorwarth, Daniela |
author_facet | Winter, René M. Leibfarth, Sara Schmidt, Holger Zwirner, Kerstin Mönnich, David Welz, Stefan Schwenzer, Nina F. la Fougère, Christian Nikolaou, Konstantin Gatidis, Sergios Zips, Daniel Thorwarth, Daniela |
author_sort | Winter, René M. |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Functional PET/MRI has great potential to improve radiotherapy planning (RTP). However, data integration requires imaging with radiotherapy-specific patient positioning. Here, we investigated the feasibility and image quality of radiotherapy-customized PET/MRI in head-and-neck cancer (HNC) patients using a dedicated hardware setup. MATERIAL AND METHODS: Ten HNC patients were examined with simultaneous PET/MRI before treatment, with radiotherapy and diagnostic scan setup, respectively. We tested feasibility of radiotherapy-specific patient positioning and compared the image quality between both setups by pairwise image analysis of (18)F-FDG-PET, T1/T2-weighted and diffusion-weighted MRI. For image quality assessment, similarity measures including average symmetric surface distance (ASSD) of PET and MR-based tumor contours, MR signal-to-noise ratio (SNR) and mean apparent diffusion coefficient (ADC) value were used. RESULTS: PET/MRI in radiotherapy position was feasible – all patients were successfully examined. ASSD (median/range) of PET and MR contours was 0.6 (0.4–1.2) and 0.9 (0.5–1.3) mm, respectively. For T2-weighted MRI, a reduced SNR of −26.2% (−39.0–−11.7) was observed with radiotherapy setup. No significant difference in mean ADC was found. CONCLUSIONS: Simultaneous PET/MRI in HNC patients using radiotherapy positioning aids is clinically feasible. Though SNR was reduced, the image quality obtained with a radiotherapy setup meets RTP requirements and the data can thus be used for personalized RTP. |
format | Online Article Text |
id | pubmed-6141811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier Scientific Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-61418112018-09-20 Assessment of image quality of a radiotherapy-specific hardware solution for PET/MRI in head and neck cancer patients Winter, René M. Leibfarth, Sara Schmidt, Holger Zwirner, Kerstin Mönnich, David Welz, Stefan Schwenzer, Nina F. la Fougère, Christian Nikolaou, Konstantin Gatidis, Sergios Zips, Daniel Thorwarth, Daniela Radiother Oncol Article BACKGROUND AND PURPOSE: Functional PET/MRI has great potential to improve radiotherapy planning (RTP). However, data integration requires imaging with radiotherapy-specific patient positioning. Here, we investigated the feasibility and image quality of radiotherapy-customized PET/MRI in head-and-neck cancer (HNC) patients using a dedicated hardware setup. MATERIAL AND METHODS: Ten HNC patients were examined with simultaneous PET/MRI before treatment, with radiotherapy and diagnostic scan setup, respectively. We tested feasibility of radiotherapy-specific patient positioning and compared the image quality between both setups by pairwise image analysis of (18)F-FDG-PET, T1/T2-weighted and diffusion-weighted MRI. For image quality assessment, similarity measures including average symmetric surface distance (ASSD) of PET and MR-based tumor contours, MR signal-to-noise ratio (SNR) and mean apparent diffusion coefficient (ADC) value were used. RESULTS: PET/MRI in radiotherapy position was feasible – all patients were successfully examined. ASSD (median/range) of PET and MR contours was 0.6 (0.4–1.2) and 0.9 (0.5–1.3) mm, respectively. For T2-weighted MRI, a reduced SNR of −26.2% (−39.0–−11.7) was observed with radiotherapy setup. No significant difference in mean ADC was found. CONCLUSIONS: Simultaneous PET/MRI in HNC patients using radiotherapy positioning aids is clinically feasible. Though SNR was reduced, the image quality obtained with a radiotherapy setup meets RTP requirements and the data can thus be used for personalized RTP. Elsevier Scientific Publishers 2018-09 /pmc/articles/PMC6141811/ /pubmed/29747873 http://dx.doi.org/10.1016/j.radonc.2018.04.018 Text en © 2018 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Winter, René M. Leibfarth, Sara Schmidt, Holger Zwirner, Kerstin Mönnich, David Welz, Stefan Schwenzer, Nina F. la Fougère, Christian Nikolaou, Konstantin Gatidis, Sergios Zips, Daniel Thorwarth, Daniela Assessment of image quality of a radiotherapy-specific hardware solution for PET/MRI in head and neck cancer patients |
title | Assessment of image quality of a radiotherapy-specific hardware solution for PET/MRI in head and neck cancer patients |
title_full | Assessment of image quality of a radiotherapy-specific hardware solution for PET/MRI in head and neck cancer patients |
title_fullStr | Assessment of image quality of a radiotherapy-specific hardware solution for PET/MRI in head and neck cancer patients |
title_full_unstemmed | Assessment of image quality of a radiotherapy-specific hardware solution for PET/MRI in head and neck cancer patients |
title_short | Assessment of image quality of a radiotherapy-specific hardware solution for PET/MRI in head and neck cancer patients |
title_sort | assessment of image quality of a radiotherapy-specific hardware solution for pet/mri in head and neck cancer patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141811/ https://www.ncbi.nlm.nih.gov/pubmed/29747873 http://dx.doi.org/10.1016/j.radonc.2018.04.018 |
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