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Antinuclear antibodies in healthy people and non-rheumatic diseases – diagnostic and clinical implications
The presence of antinuclear antibodies (ANA) is mainly associated with connective tissue diseases (CTD). In addition, their presence is found in healthy people. These antibodies are more common in women and the elderly. Some drugs and xenobiotics are also important for the development of autoimmunit...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142026/ https://www.ncbi.nlm.nih.gov/pubmed/30237629 http://dx.doi.org/10.5114/reum.2018.77976 |
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author | Grygiel-Górniak, Bogna Rogacka, Natalia Puszczewicz, Mariusz |
author_facet | Grygiel-Górniak, Bogna Rogacka, Natalia Puszczewicz, Mariusz |
author_sort | Grygiel-Górniak, Bogna |
collection | PubMed |
description | The presence of antinuclear antibodies (ANA) is mainly associated with connective tissue diseases (CTD). In addition, their presence is found in healthy people. These antibodies are more common in women and the elderly. Some drugs and xenobiotics are also important for the development of autoimmunity and ANA synthesis. Moreover, the deficiency of vitamin D in the body of patients correlates with occurrence of these antibodies. Unlike the healthy group, a positive ANA count was observed in patients with atopic dermatitis (AD) and in people with immune disorders. Antinuclear antibodies in low counts are also found in the course of chronic bacterial or viral infection and in patients with hematological malignancies. Also the possibility of false positive results, which may be caused by the choice of method used to determine antibodies, should be borne in mind. Taking into account all these factors, it is concluded that the ANA result itself has no diagnostic value. |
format | Online Article Text |
id | pubmed-6142026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie |
record_format | MEDLINE/PubMed |
spelling | pubmed-61420262018-09-20 Antinuclear antibodies in healthy people and non-rheumatic diseases – diagnostic and clinical implications Grygiel-Górniak, Bogna Rogacka, Natalia Puszczewicz, Mariusz Reumatologia Review Paper The presence of antinuclear antibodies (ANA) is mainly associated with connective tissue diseases (CTD). In addition, their presence is found in healthy people. These antibodies are more common in women and the elderly. Some drugs and xenobiotics are also important for the development of autoimmunity and ANA synthesis. Moreover, the deficiency of vitamin D in the body of patients correlates with occurrence of these antibodies. Unlike the healthy group, a positive ANA count was observed in patients with atopic dermatitis (AD) and in people with immune disorders. Antinuclear antibodies in low counts are also found in the course of chronic bacterial or viral infection and in patients with hematological malignancies. Also the possibility of false positive results, which may be caused by the choice of method used to determine antibodies, should be borne in mind. Taking into account all these factors, it is concluded that the ANA result itself has no diagnostic value. Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2018-08-31 2018 /pmc/articles/PMC6142026/ /pubmed/30237629 http://dx.doi.org/10.5114/reum.2018.77976 Text en Copyright: © 2018 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Review Paper Grygiel-Górniak, Bogna Rogacka, Natalia Puszczewicz, Mariusz Antinuclear antibodies in healthy people and non-rheumatic diseases – diagnostic and clinical implications |
title | Antinuclear antibodies in healthy people and non-rheumatic diseases – diagnostic and clinical implications |
title_full | Antinuclear antibodies in healthy people and non-rheumatic diseases – diagnostic and clinical implications |
title_fullStr | Antinuclear antibodies in healthy people and non-rheumatic diseases – diagnostic and clinical implications |
title_full_unstemmed | Antinuclear antibodies in healthy people and non-rheumatic diseases – diagnostic and clinical implications |
title_short | Antinuclear antibodies in healthy people and non-rheumatic diseases – diagnostic and clinical implications |
title_sort | antinuclear antibodies in healthy people and non-rheumatic diseases – diagnostic and clinical implications |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142026/ https://www.ncbi.nlm.nih.gov/pubmed/30237629 http://dx.doi.org/10.5114/reum.2018.77976 |
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