Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma

Renal oncocytomas are benign tumors characterized by a marked accumulation of mitochondria. We report a combined exome, transcriptome, and metabolome analysis of these tumors. Joint analysis of the nuclear and mitochondrial (mtDNA) genomes reveals loss-of-function mtDNA mutations occurring at high v...

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Detalles Bibliográficos
Autores principales: Gopal, Raj K., Calvo, Sarah E., Shih, Angela R., Chaves, Frances L., McGuone, Declan, Mick, Eran, Pierce, Kerry A., Li, Yang, Garofalo, Andrea, Van Allen, Eliezer M., Clish, Clary B., Oliva, Esther, Mootha, Vamsi K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142220/
https://www.ncbi.nlm.nih.gov/pubmed/29915083
http://dx.doi.org/10.1073/pnas.1711888115

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