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Systematic evaluation of signal-to-noise ratio in variant detection from single cell genome multiple displacement amplification and exome sequencing

BACKGROUND: The current literature on single cell genomic analyses on the DNA level is conflicting regarding requirements for cell quality, amplification success rates, allelic dropouts and resolution, lacking a systematic comparison of multiple cell input down to the single cell. We hypothesized th...

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Detalles Bibliográficos
Autores principales:	Simonsen, Anita T., Hansen, Marcus C., Kjeldsen, Eigil, Møller, Peter L., Hindkjær, Johnny J., Hokland, Peter, Aggerholm, Anni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142419/ https://www.ncbi.nlm.nih.gov/pubmed/30223769 http://dx.doi.org/10.1186/s12864-018-5063-5

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