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Comparison of clinical efficacy and complications of (125)I seed brachytherapy and stereotactic body radiation therapy for recurrent pulmonary metastases from colorectal carcinoma

PURPOSE: To evaluate the efficacies of (125)I seed implantation and stereotactic body radiation therapy (SBRT) in treatment of recurrent lung metastases from colorectal cancer, to compare the tolerance of lung tissue to both forms of radiotherapy, and to analyze the factors that affect the prognosis...

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Autores principales: Li, Jie, Zhang, Lijuan, Xie, Qigen, Wang, Weiguo, Hua, Yanyan, Sun, Zongqiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142642/
https://www.ncbi.nlm.nih.gov/pubmed/30237819
http://dx.doi.org/10.5114/jcb.2018.77956
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author Li, Jie
Zhang, Lijuan
Xie, Qigen
Wang, Weiguo
Hua, Yanyan
Sun, Zongqiong
author_facet Li, Jie
Zhang, Lijuan
Xie, Qigen
Wang, Weiguo
Hua, Yanyan
Sun, Zongqiong
author_sort Li, Jie
collection PubMed
description PURPOSE: To evaluate the efficacies of (125)I seed implantation and stereotactic body radiation therapy (SBRT) in treatment of recurrent lung metastases from colorectal cancer, to compare the tolerance of lung tissue to both forms of radiotherapy, and to analyze the factors that affect the prognosis. MATERIAL AND METHODS: According to treatment received, thirty colorectal cancer patients with post-operative lung metastases were separated into two groups: (125)I seed implantation group (group A; n = 16) and SBRT group (group B; n = 14). Patients were followed up, and local control rate, survival, and post-operative complications were analyzed retrospectively. Kaplan-Meier method was used for survival analysis. Cox proportional hazards model was used to identify the independent predictors of poor prognosis. RESULTS: Survival was significantly different between group A and group B (median survival, 15 months and 11.5 months, respectively; p = 0.015). Local control rates at the first, third, sixth, and twelfth months after treatment were all > 80%, with no significant difference between the two groups (p = 0.829). Significant differences were seen between the two groups in the number of treatments received (p = 0.009) and the incidence of radiation pneumonitis (p < 0.001) as well as radiation-induced pulmonary fibrosis (p = 0.005). On multivariate regression analysis radiation pneumonitis was an independent predictor of poor prognosis (HR = 3.356, 95% CI: 1.518-7.421; p = 0.003). CONCLUSIONS: (125)I seeds brachytherapy and SBRT are both effective for control of lung metastases but the former causes milder lung tissue damage. It can be repeated after short intervals, and appears to be a safe and efficient treatment for lung metastases.
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spelling pubmed-61426422018-09-20 Comparison of clinical efficacy and complications of (125)I seed brachytherapy and stereotactic body radiation therapy for recurrent pulmonary metastases from colorectal carcinoma Li, Jie Zhang, Lijuan Xie, Qigen Wang, Weiguo Hua, Yanyan Sun, Zongqiong J Contemp Brachytherapy Original Paper PURPOSE: To evaluate the efficacies of (125)I seed implantation and stereotactic body radiation therapy (SBRT) in treatment of recurrent lung metastases from colorectal cancer, to compare the tolerance of lung tissue to both forms of radiotherapy, and to analyze the factors that affect the prognosis. MATERIAL AND METHODS: According to treatment received, thirty colorectal cancer patients with post-operative lung metastases were separated into two groups: (125)I seed implantation group (group A; n = 16) and SBRT group (group B; n = 14). Patients were followed up, and local control rate, survival, and post-operative complications were analyzed retrospectively. Kaplan-Meier method was used for survival analysis. Cox proportional hazards model was used to identify the independent predictors of poor prognosis. RESULTS: Survival was significantly different between group A and group B (median survival, 15 months and 11.5 months, respectively; p = 0.015). Local control rates at the first, third, sixth, and twelfth months after treatment were all > 80%, with no significant difference between the two groups (p = 0.829). Significant differences were seen between the two groups in the number of treatments received (p = 0.009) and the incidence of radiation pneumonitis (p < 0.001) as well as radiation-induced pulmonary fibrosis (p = 0.005). On multivariate regression analysis radiation pneumonitis was an independent predictor of poor prognosis (HR = 3.356, 95% CI: 1.518-7.421; p = 0.003). CONCLUSIONS: (125)I seeds brachytherapy and SBRT are both effective for control of lung metastases but the former causes milder lung tissue damage. It can be repeated after short intervals, and appears to be a safe and efficient treatment for lung metastases. Termedia Publishing House 2018-08-31 2018-08 /pmc/articles/PMC6142642/ /pubmed/30237819 http://dx.doi.org/10.5114/jcb.2018.77956 Text en Copyright: © 2018 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Li, Jie
Zhang, Lijuan
Xie, Qigen
Wang, Weiguo
Hua, Yanyan
Sun, Zongqiong
Comparison of clinical efficacy and complications of (125)I seed brachytherapy and stereotactic body radiation therapy for recurrent pulmonary metastases from colorectal carcinoma
title Comparison of clinical efficacy and complications of (125)I seed brachytherapy and stereotactic body radiation therapy for recurrent pulmonary metastases from colorectal carcinoma
title_full Comparison of clinical efficacy and complications of (125)I seed brachytherapy and stereotactic body radiation therapy for recurrent pulmonary metastases from colorectal carcinoma
title_fullStr Comparison of clinical efficacy and complications of (125)I seed brachytherapy and stereotactic body radiation therapy for recurrent pulmonary metastases from colorectal carcinoma
title_full_unstemmed Comparison of clinical efficacy and complications of (125)I seed brachytherapy and stereotactic body radiation therapy for recurrent pulmonary metastases from colorectal carcinoma
title_short Comparison of clinical efficacy and complications of (125)I seed brachytherapy and stereotactic body radiation therapy for recurrent pulmonary metastases from colorectal carcinoma
title_sort comparison of clinical efficacy and complications of (125)i seed brachytherapy and stereotactic body radiation therapy for recurrent pulmonary metastases from colorectal carcinoma
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142642/
https://www.ncbi.nlm.nih.gov/pubmed/30237819
http://dx.doi.org/10.5114/jcb.2018.77956
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