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Effectiveness and safety of a robot-assisted 3D personalized template in (125)I seed brachytherapy of thoracoabdominal tumors

PURPOSE: This research aims to evaluate the effectiveness and safety of a robot-assisted 3D personalized template in (125)I seed brachytherapy of thoracoabdominal tumors. MATERIAL AND METHODS: Forty-three patients with different tumors were involved in this research between 2013 and 2015. They were...

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Autores principales: Ma, Xiaodong, Yang, Prof. Zhiyong, Jiang, Prof. Shan, Huo, Prof. Bin, Cao, Qiang, Chai, Prof. Shude, Wang, Prof. Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142644/
https://www.ncbi.nlm.nih.gov/pubmed/30237820
http://dx.doi.org/10.5114/jcb.2018.77957
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author Ma, Xiaodong
Yang, Prof. Zhiyong
Jiang, Prof. Shan
Huo, Prof. Bin
Cao, Qiang
Chai, Prof. Shude
Wang, Prof. Haitao
author_facet Ma, Xiaodong
Yang, Prof. Zhiyong
Jiang, Prof. Shan
Huo, Prof. Bin
Cao, Qiang
Chai, Prof. Shude
Wang, Prof. Haitao
author_sort Ma, Xiaodong
collection PubMed
description PURPOSE: This research aims to evaluate the effectiveness and safety of a robot-assisted 3D personalized template in (125)I seed brachytherapy of thoracoabdominal tumors. MATERIAL AND METHODS: Forty-three patients with different tumors were involved in this research between 2013 and 2015. They were all eligible to (125)I seed implantation based on robot-assisted 3D personalized template. Meanwhile, 51 patients with similar tumors, which were treated with a conventional coplanar template, were involved for comparison. Follow-up was carried out after the surgery to evaluate the therapeutic efficacy, including overall survival (OS) of the patient and local control (LC) of the tumor. Complications were also summarized to evaluate the safety. Besides, statistical analysis was achieved to investigate possible factors associated with the result. RESULTS: In the robot-assisted 3D personalized template-guided brachytherapy, the median target volume treated by the prescription dose (V(100)) was 95.3% (range, 92.4-109.8), and the median dose administered to 90% of the target volume (D(90)) was 126.1 Gy (range, 114.2-132.0), improved 5% and 8% compared with the conventional template-guided brachytherapy, respectively. The median OS was 30 months (95% CI: 19.4-40.6) and the rates of 2-year OS and LC were 58.1% and 86.0%, respectively. The median OS was prolonged 10 months and the 2-year OS and LC were improved 18.9% and 23.3% compared with the conventional template-guided brachytherapy, respectively. CONCLUSIONS: Through analysis of the selected patients with thoracoabdominal tumors, the robot-assisted 3D personalized template in (125)I seed brachytherapy was a more effective and safer method. It can achieve a more favorable OS and LC.
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spelling pubmed-61426442018-09-20 Effectiveness and safety of a robot-assisted 3D personalized template in (125)I seed brachytherapy of thoracoabdominal tumors Ma, Xiaodong Yang, Prof. Zhiyong Jiang, Prof. Shan Huo, Prof. Bin Cao, Qiang Chai, Prof. Shude Wang, Prof. Haitao J Contemp Brachytherapy Original Paper PURPOSE: This research aims to evaluate the effectiveness and safety of a robot-assisted 3D personalized template in (125)I seed brachytherapy of thoracoabdominal tumors. MATERIAL AND METHODS: Forty-three patients with different tumors were involved in this research between 2013 and 2015. They were all eligible to (125)I seed implantation based on robot-assisted 3D personalized template. Meanwhile, 51 patients with similar tumors, which were treated with a conventional coplanar template, were involved for comparison. Follow-up was carried out after the surgery to evaluate the therapeutic efficacy, including overall survival (OS) of the patient and local control (LC) of the tumor. Complications were also summarized to evaluate the safety. Besides, statistical analysis was achieved to investigate possible factors associated with the result. RESULTS: In the robot-assisted 3D personalized template-guided brachytherapy, the median target volume treated by the prescription dose (V(100)) was 95.3% (range, 92.4-109.8), and the median dose administered to 90% of the target volume (D(90)) was 126.1 Gy (range, 114.2-132.0), improved 5% and 8% compared with the conventional template-guided brachytherapy, respectively. The median OS was 30 months (95% CI: 19.4-40.6) and the rates of 2-year OS and LC were 58.1% and 86.0%, respectively. The median OS was prolonged 10 months and the 2-year OS and LC were improved 18.9% and 23.3% compared with the conventional template-guided brachytherapy, respectively. CONCLUSIONS: Through analysis of the selected patients with thoracoabdominal tumors, the robot-assisted 3D personalized template in (125)I seed brachytherapy was a more effective and safer method. It can achieve a more favorable OS and LC. Termedia Publishing House 2018-08-31 2018-08 /pmc/articles/PMC6142644/ /pubmed/30237820 http://dx.doi.org/10.5114/jcb.2018.77957 Text en Copyright: © 2018 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Ma, Xiaodong
Yang, Prof. Zhiyong
Jiang, Prof. Shan
Huo, Prof. Bin
Cao, Qiang
Chai, Prof. Shude
Wang, Prof. Haitao
Effectiveness and safety of a robot-assisted 3D personalized template in (125)I seed brachytherapy of thoracoabdominal tumors
title Effectiveness and safety of a robot-assisted 3D personalized template in (125)I seed brachytherapy of thoracoabdominal tumors
title_full Effectiveness and safety of a robot-assisted 3D personalized template in (125)I seed brachytherapy of thoracoabdominal tumors
title_fullStr Effectiveness and safety of a robot-assisted 3D personalized template in (125)I seed brachytherapy of thoracoabdominal tumors
title_full_unstemmed Effectiveness and safety of a robot-assisted 3D personalized template in (125)I seed brachytherapy of thoracoabdominal tumors
title_short Effectiveness and safety of a robot-assisted 3D personalized template in (125)I seed brachytherapy of thoracoabdominal tumors
title_sort effectiveness and safety of a robot-assisted 3d personalized template in (125)i seed brachytherapy of thoracoabdominal tumors
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142644/
https://www.ncbi.nlm.nih.gov/pubmed/30237820
http://dx.doi.org/10.5114/jcb.2018.77957
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