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Pre-implant magnetic resonance and transrectal ultrasound imaging in high-dose-rate prostate brachytherapy: comparison of prostate volumes, craniocaudal extents, and contours

PURPOSE: The purpose of this study was to compare the prostate contours drawn by two radiation oncologists and one radiologist on magnetic resonance (MR) and transrectal ultrasound (TRUS) images. TRUS intra- and inter-fraction variability as well as TRUS vs. MR inter-modality and inter-operator vari...

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Autores principales: Grisotto, Simone, Cerrotta, Annamaria, Pappalardi, Brigida, Carrara, Mauro, Messina, Antonella, Tenconi, Chiara, Valdagni, Riccardo, Fallai, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142648/
https://www.ncbi.nlm.nih.gov/pubmed/30237811
http://dx.doi.org/10.5114/jcb.2018.77947
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author Grisotto, Simone
Cerrotta, Annamaria
Pappalardi, Brigida
Carrara, Mauro
Messina, Antonella
Tenconi, Chiara
Valdagni, Riccardo
Fallai, Carlo
author_facet Grisotto, Simone
Cerrotta, Annamaria
Pappalardi, Brigida
Carrara, Mauro
Messina, Antonella
Tenconi, Chiara
Valdagni, Riccardo
Fallai, Carlo
author_sort Grisotto, Simone
collection PubMed
description PURPOSE: The purpose of this study was to compare the prostate contours drawn by two radiation oncologists and one radiologist on magnetic resonance (MR) and transrectal ultrasound (TRUS) images. TRUS intra- and inter-fraction variability as well as TRUS vs. MR inter-modality and inter-operator variability were studied. MATERIAL AND METHODS: Thirty patients affected by localized prostate cancer and treated with interstitial high-dose-rate (HDR) prostate brachytherapy at the National Cancer Institute in Milan were included in this study. Twenty-five patients received an exclusive two-fraction (14 Gy/fraction) treatment, while the other 5 received a single 14 Gy fraction as a boost after external beam radiotherapy. The prostate was contoured on TRUS images acquired before (virtual US) and after (real US) needle implant by two radiation oncologists, whereas on MR prostate was independently contoured by the same radiation oncologists (MR1, MR2) and by a dedicated radiologist (MR3). Absolute differences of prostate volumes (│ΔV│) and craniocaudal extents (│Δdz│) were evaluated. The Dice’s coefficient (DC) was calculated to quantify spatial overlap between MR contours. RESULTS: Significant difference was found between V(virtual) and V(live) (p < 0.001) for the first treatment fractions and between V(MR1) and V(MR2) (p = 0.043). Significant difference between cranio-caudal extents was found between dz(virtual) and dz(live) (p < 0.033) for the first treatment fractions, between dz(virtual) of the first treatment fractions and dz(MR1) (p < 0.001) and between dz(MR1) and dz(MR3) (p < 0.01). Oedema might be responsible for some of the changes in US volumes. Average DC values resulting from the comparison MR1 vs. MR2, MR1 vs. MR3 and MR2 vs. MR3 were 0.95 ± 0.04 (range, 0.82-0.99), 0.87 ± 0.04 (range, 0.73-0.91) and 0.87 ± 0.04 (range, 0.72-0.91), respectively. CONCLUSIONS: Our results demonstrate the importance of a multiprofessional approach to TRUS-guided HDR prostate brachytherapy. Specific training in MR and US prostate imaging is recommended for centers that are unfamiliar with HDR prostate brachytherapy.
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spelling pubmed-61426482018-09-20 Pre-implant magnetic resonance and transrectal ultrasound imaging in high-dose-rate prostate brachytherapy: comparison of prostate volumes, craniocaudal extents, and contours Grisotto, Simone Cerrotta, Annamaria Pappalardi, Brigida Carrara, Mauro Messina, Antonella Tenconi, Chiara Valdagni, Riccardo Fallai, Carlo J Contemp Brachytherapy Original Paper PURPOSE: The purpose of this study was to compare the prostate contours drawn by two radiation oncologists and one radiologist on magnetic resonance (MR) and transrectal ultrasound (TRUS) images. TRUS intra- and inter-fraction variability as well as TRUS vs. MR inter-modality and inter-operator variability were studied. MATERIAL AND METHODS: Thirty patients affected by localized prostate cancer and treated with interstitial high-dose-rate (HDR) prostate brachytherapy at the National Cancer Institute in Milan were included in this study. Twenty-five patients received an exclusive two-fraction (14 Gy/fraction) treatment, while the other 5 received a single 14 Gy fraction as a boost after external beam radiotherapy. The prostate was contoured on TRUS images acquired before (virtual US) and after (real US) needle implant by two radiation oncologists, whereas on MR prostate was independently contoured by the same radiation oncologists (MR1, MR2) and by a dedicated radiologist (MR3). Absolute differences of prostate volumes (│ΔV│) and craniocaudal extents (│Δdz│) were evaluated. The Dice’s coefficient (DC) was calculated to quantify spatial overlap between MR contours. RESULTS: Significant difference was found between V(virtual) and V(live) (p < 0.001) for the first treatment fractions and between V(MR1) and V(MR2) (p = 0.043). Significant difference between cranio-caudal extents was found between dz(virtual) and dz(live) (p < 0.033) for the first treatment fractions, between dz(virtual) of the first treatment fractions and dz(MR1) (p < 0.001) and between dz(MR1) and dz(MR3) (p < 0.01). Oedema might be responsible for some of the changes in US volumes. Average DC values resulting from the comparison MR1 vs. MR2, MR1 vs. MR3 and MR2 vs. MR3 were 0.95 ± 0.04 (range, 0.82-0.99), 0.87 ± 0.04 (range, 0.73-0.91) and 0.87 ± 0.04 (range, 0.72-0.91), respectively. CONCLUSIONS: Our results demonstrate the importance of a multiprofessional approach to TRUS-guided HDR prostate brachytherapy. Specific training in MR and US prostate imaging is recommended for centers that are unfamiliar with HDR prostate brachytherapy. Termedia Publishing House 2018-08-31 2018-08 /pmc/articles/PMC6142648/ /pubmed/30237811 http://dx.doi.org/10.5114/jcb.2018.77947 Text en Copyright: © 2018 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Grisotto, Simone
Cerrotta, Annamaria
Pappalardi, Brigida
Carrara, Mauro
Messina, Antonella
Tenconi, Chiara
Valdagni, Riccardo
Fallai, Carlo
Pre-implant magnetic resonance and transrectal ultrasound imaging in high-dose-rate prostate brachytherapy: comparison of prostate volumes, craniocaudal extents, and contours
title Pre-implant magnetic resonance and transrectal ultrasound imaging in high-dose-rate prostate brachytherapy: comparison of prostate volumes, craniocaudal extents, and contours
title_full Pre-implant magnetic resonance and transrectal ultrasound imaging in high-dose-rate prostate brachytherapy: comparison of prostate volumes, craniocaudal extents, and contours
title_fullStr Pre-implant magnetic resonance and transrectal ultrasound imaging in high-dose-rate prostate brachytherapy: comparison of prostate volumes, craniocaudal extents, and contours
title_full_unstemmed Pre-implant magnetic resonance and transrectal ultrasound imaging in high-dose-rate prostate brachytherapy: comparison of prostate volumes, craniocaudal extents, and contours
title_short Pre-implant magnetic resonance and transrectal ultrasound imaging in high-dose-rate prostate brachytherapy: comparison of prostate volumes, craniocaudal extents, and contours
title_sort pre-implant magnetic resonance and transrectal ultrasound imaging in high-dose-rate prostate brachytherapy: comparison of prostate volumes, craniocaudal extents, and contours
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142648/
https://www.ncbi.nlm.nih.gov/pubmed/30237811
http://dx.doi.org/10.5114/jcb.2018.77947
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