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Nucleoside macrocycles formed by intramolecular click reaction: efficient cyclization of pyrimidine nucleosides decorated with 5'-azido residues and 5-octadiynyl side chains

Copper(I)-promoted "click" cyclization in the presence of TBTA afforded nucleoside macrocycles in very high yields (≈70%) without using protecting groups. To this end, dU and dC derivatives functionalized at the 5-position of the nucleobase with octadiynyl side chains and with azido groups...

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Detalles Bibliográficos
Autores principales: Liu, Jiang, Leonard, Peter, Müller, Sebastian L, Daniliuc, Constantin, Seela, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142766/
https://www.ncbi.nlm.nih.gov/pubmed/30254706
http://dx.doi.org/10.3762/bjoc.14.217

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