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Nucleoside macrocycles formed by intramolecular click reaction: efficient cyclization of pyrimidine nucleosides decorated with 5'-azido residues and 5-octadiynyl side chains

Copper(I)-promoted "click" cyclization in the presence of TBTA afforded nucleoside macrocycles in very high yields (≈70%) without using protecting groups. To this end, dU and dC derivatives functionalized at the 5-position of the nucleobase with octadiynyl side chains and with azido groups...

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Detalles Bibliográficos
Autores principales:	Liu, Jiang, Leonard, Peter, Müller, Sebastian L, Daniliuc, Constantin, Seela, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2018
Materias:	Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142766/ https://www.ncbi.nlm.nih.gov/pubmed/30254706 http://dx.doi.org/10.3762/bjoc.14.217

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