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The Unexpected Essentiality of glnA2 in Mycobacterium smegmatis Is Salvaged by Overexpression of the Global Nitrogen Regulator glnR, but Not by L-, D- or Iso-Glutamine

Nitrogen metabolism plays a central role in the physiology of microorganisms, and Glutamine Synthetase (GS) genes are present in virtually all bacteria. In M. tuberculosis, four GS genes are present, but only glnA1 is essential, whereas glnA2 was shown to be non-essential for in-vitro as well as in-...

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Detalles Bibliográficos
Autores principales:	Rakovitsky, Nadya, Bar Oz, Michal, Goldberg, Karin, Gibbons, Simon, Zimhony, Oren, Barkan, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142876/ https://www.ncbi.nlm.nih.gov/pubmed/30271391 http://dx.doi.org/10.3389/fmicb.2018.02143

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