Cargando…
Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for EsxW Beijing variant in Vietnam
To examine transmission dynamics of Mtb isolated from TB patients in Ho Chi Minh City, Vietnam we sequenced whole genomes of 1,635 isolates and compared these with 3,144 isolates from elsewhere. The data reveal an underlying burden of disease caused by endemic Mtb Lineage 1 associated with activatio...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143168/ https://www.ncbi.nlm.nih.gov/pubmed/29785015 http://dx.doi.org/10.1038/s41588-018-0117-9 |
_version_ | 1783355930594770944 |
---|---|
author | Holt, Kathryn E McAdam, Paul Thai, Phan Vuong Khac Thuong, Nguyen Thuy Thuong Ha, Dang Thi Minh Lan, Nguyen Ngoc Lan, Nguyen Huu Nhu, Nguyen Thi Quynh Hai, Hoang Thanh Ha, Vu Thi Ngoc Thwaites, Guy Edwards, David J Nath, Artika P Pham, Kym Ascher, David B Farrar, Jeremy Khor, Chiea Chuen Teo, Yik Ying Inouye, Michael Caws, Maxine Dunstan, Sarah J |
author_facet | Holt, Kathryn E McAdam, Paul Thai, Phan Vuong Khac Thuong, Nguyen Thuy Thuong Ha, Dang Thi Minh Lan, Nguyen Ngoc Lan, Nguyen Huu Nhu, Nguyen Thi Quynh Hai, Hoang Thanh Ha, Vu Thi Ngoc Thwaites, Guy Edwards, David J Nath, Artika P Pham, Kym Ascher, David B Farrar, Jeremy Khor, Chiea Chuen Teo, Yik Ying Inouye, Michael Caws, Maxine Dunstan, Sarah J |
author_sort | Holt, Kathryn E |
collection | PubMed |
description | To examine transmission dynamics of Mtb isolated from TB patients in Ho Chi Minh City, Vietnam we sequenced whole genomes of 1,635 isolates and compared these with 3,144 isolates from elsewhere. The data reveal an underlying burden of disease caused by endemic Mtb Lineage 1 associated with activation of long-term latent infection, and a three-fold higher burden associated with more recently introduced Beijing lineage and Lineage 4 Mtb strains. We find that Beijing lineage Mtb is frequently transferred between Vietnam and other countries, and detect higher levels of transmission of Beijing lineage strains within this host population than endemic Lineage 1 Mtb. Screening for parallel evolution of Beijing lineage-associated SNPs in other Mtb lineages as a signal of positive selection, we identify a mutation in the ESX-5 type VII secreted protein EsxW, which could potentially contribute to the enhanced transmission of Beijing lineage Mtb in Vietnamese and other host populations. |
format | Online Article Text |
id | pubmed-6143168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
record_format | MEDLINE/PubMed |
spelling | pubmed-61431682018-11-21 Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for EsxW Beijing variant in Vietnam Holt, Kathryn E McAdam, Paul Thai, Phan Vuong Khac Thuong, Nguyen Thuy Thuong Ha, Dang Thi Minh Lan, Nguyen Ngoc Lan, Nguyen Huu Nhu, Nguyen Thi Quynh Hai, Hoang Thanh Ha, Vu Thi Ngoc Thwaites, Guy Edwards, David J Nath, Artika P Pham, Kym Ascher, David B Farrar, Jeremy Khor, Chiea Chuen Teo, Yik Ying Inouye, Michael Caws, Maxine Dunstan, Sarah J Nat Genet Article To examine transmission dynamics of Mtb isolated from TB patients in Ho Chi Minh City, Vietnam we sequenced whole genomes of 1,635 isolates and compared these with 3,144 isolates from elsewhere. The data reveal an underlying burden of disease caused by endemic Mtb Lineage 1 associated with activation of long-term latent infection, and a three-fold higher burden associated with more recently introduced Beijing lineage and Lineage 4 Mtb strains. We find that Beijing lineage Mtb is frequently transferred between Vietnam and other countries, and detect higher levels of transmission of Beijing lineage strains within this host population than endemic Lineage 1 Mtb. Screening for parallel evolution of Beijing lineage-associated SNPs in other Mtb lineages as a signal of positive selection, we identify a mutation in the ESX-5 type VII secreted protein EsxW, which could potentially contribute to the enhanced transmission of Beijing lineage Mtb in Vietnamese and other host populations. 2018-05-21 2018-06 /pmc/articles/PMC6143168/ /pubmed/29785015 http://dx.doi.org/10.1038/s41588-018-0117-9 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Holt, Kathryn E McAdam, Paul Thai, Phan Vuong Khac Thuong, Nguyen Thuy Thuong Ha, Dang Thi Minh Lan, Nguyen Ngoc Lan, Nguyen Huu Nhu, Nguyen Thi Quynh Hai, Hoang Thanh Ha, Vu Thi Ngoc Thwaites, Guy Edwards, David J Nath, Artika P Pham, Kym Ascher, David B Farrar, Jeremy Khor, Chiea Chuen Teo, Yik Ying Inouye, Michael Caws, Maxine Dunstan, Sarah J Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for EsxW Beijing variant in Vietnam |
title | Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for EsxW Beijing variant in Vietnam |
title_full | Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for EsxW Beijing variant in Vietnam |
title_fullStr | Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for EsxW Beijing variant in Vietnam |
title_full_unstemmed | Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for EsxW Beijing variant in Vietnam |
title_short | Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for EsxW Beijing variant in Vietnam |
title_sort | frequent transmission of the mycobacterium tuberculosis beijing lineage and positive selection for esxw beijing variant in vietnam |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143168/ https://www.ncbi.nlm.nih.gov/pubmed/29785015 http://dx.doi.org/10.1038/s41588-018-0117-9 |
work_keys_str_mv | AT holtkathryne frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT mcadampaul frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT thaiphanvuongkhac frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT thuongnguyenthuythuong frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT hadangthiminh frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT lannguyenngoc frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT lannguyenhuu frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT nhunguyenthiquynh frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT haihoangthanh frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT havuthingoc frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT thwaitesguy frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT edwardsdavidj frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT nathartikap frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT phamkym frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT ascherdavidb frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT farrarjeremy frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT khorchieachuen frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT teoyikying frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT inouyemichael frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT cawsmaxine frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam AT dunstansarahj frequenttransmissionofthemycobacteriumtuberculosisbeijinglineageandpositiveselectionforesxwbeijingvariantinvietnam |