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CLEC16A regulates splenocyte and NK cell function in part through MEK signaling

CLEC16A is implicated in multiple autoimmune diseases. We generated Clec16a inducible knockout (KO) mice to examine the functional link between CLEC16A auto-inflammation and autoimmunity. Clec16a KO mice exhibited weight loss and thymic and splenic atrophy. Mitochondrial potential was lowered in KO...

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Detalles Bibliográficos
Autores principales:	Pandey, Rahul, Bakay, Marina, Hain, Heather S., Strenkowski, Bryan, Elsaqa, Barakat Z. B., Roizen, Jeffrey D., Kushner, Jake A., Orange, Jordan S., Hakonarson, Hakon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143231/ https://www.ncbi.nlm.nih.gov/pubmed/30226884 http://dx.doi.org/10.1371/journal.pone.0203952

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