ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner

Cancers must maintain their telomeres at lengths sufficient for cell survival. In several cancer subtypes, a recombination-like mechanism termed alternative lengthening of telomeres (ALT), is frequently used for telomere length maintenance. Cancers utilizing ALT often have lost functional ATRX, a ch...

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Detalles Bibliográficos
Autores principales: Brosnan-Cashman, Jacqueline A., Yuan, Ming, Graham, Mindy K., Rizzo, Anthony J., Myers, Kaylar M., Davis, Christine, Zhang, Rebecca, Esopi, David M., Raabe, Eric H., Eberhart, Charles G., Heaphy, Christopher M., Meeker, Alan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143253/
https://www.ncbi.nlm.nih.gov/pubmed/30226859
http://dx.doi.org/10.1371/journal.pone.0204159

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