Identification of therapeutic targets for inflammation in sickle cell disease (SCD) among Indian patients using gene expression data analysis

Sickle cell disease (SCD) is life-threatening hemoglobinopathy prevalent in India, Sub-Saharan Africa and Middle East. Inflammation plays a pivotal role in disease process and involves intricate interaction among leukocytes, platelets, sickle erythrocytes and vascular endothelium. Available disease...

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Autores principales: Das, Ipsita, Mishra, Hrishikesh, Khodiar, Prafulla K., Patra, Pradeep K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2018
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143353/
https://www.ncbi.nlm.nih.gov/pubmed/30262980
http://dx.doi.org/10.6026/97320630014408
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author Das, Ipsita
Mishra, Hrishikesh
Khodiar, Prafulla K.
Patra, Pradeep K.
author_facet Das, Ipsita
Mishra, Hrishikesh
Khodiar, Prafulla K.
Patra, Pradeep K.
author_sort Das, Ipsita
collection PubMed
description Sickle cell disease (SCD) is life-threatening hemoglobinopathy prevalent in India, Sub-Saharan Africa and Middle East. Inflammation plays a pivotal role in disease process and involves intricate interaction among leukocytes, platelets, sickle erythrocytes and vascular endothelium. Available disease modifying therapies are hydroxyl-urea and blood transfusion. Therefore, it is of interest to develop improved pharmacological agents for SCD. We report up-regulated genes in steady state and vaso-occlusive crisis using analysis of gene expression data obtained by microarray experiment for SCD as potential targets. The association of these targets with inflammation in pathway analysis is also documented.
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spelling pubmed-61433532018-09-27 Identification of therapeutic targets for inflammation in sickle cell disease (SCD) among Indian patients using gene expression data analysis Das, Ipsita Mishra, Hrishikesh Khodiar, Prafulla K. Patra, Pradeep K. Bioinformation Hypothesis Sickle cell disease (SCD) is life-threatening hemoglobinopathy prevalent in India, Sub-Saharan Africa and Middle East. Inflammation plays a pivotal role in disease process and involves intricate interaction among leukocytes, platelets, sickle erythrocytes and vascular endothelium. Available disease modifying therapies are hydroxyl-urea and blood transfusion. Therefore, it is of interest to develop improved pharmacological agents for SCD. We report up-regulated genes in steady state and vaso-occlusive crisis using analysis of gene expression data obtained by microarray experiment for SCD as potential targets. The association of these targets with inflammation in pathway analysis is also documented. Biomedical Informatics 2018-07-31 /pmc/articles/PMC6143353/ /pubmed/30262980 http://dx.doi.org/10.6026/97320630014408 Text en © 2018 Biomedical Informatics http://creativecommons.org/licenses/by/3.0/ This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Hypothesis
Das, Ipsita
Mishra, Hrishikesh
Khodiar, Prafulla K.
Patra, Pradeep K.
Identification of therapeutic targets for inflammation in sickle cell disease (SCD) among Indian patients using gene expression data analysis
title Identification of therapeutic targets for inflammation in sickle cell disease (SCD) among Indian patients using gene expression data analysis
title_full Identification of therapeutic targets for inflammation in sickle cell disease (SCD) among Indian patients using gene expression data analysis
title_fullStr Identification of therapeutic targets for inflammation in sickle cell disease (SCD) among Indian patients using gene expression data analysis
title_full_unstemmed Identification of therapeutic targets for inflammation in sickle cell disease (SCD) among Indian patients using gene expression data analysis
title_short Identification of therapeutic targets for inflammation in sickle cell disease (SCD) among Indian patients using gene expression data analysis
title_sort identification of therapeutic targets for inflammation in sickle cell disease (scd) among indian patients using gene expression data analysis
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143353/
https://www.ncbi.nlm.nih.gov/pubmed/30262980
http://dx.doi.org/10.6026/97320630014408
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AT khodiarprafullak identificationoftherapeutictargetsforinflammationinsicklecelldiseasescdamongindianpatientsusinggeneexpressiondataanalysis
AT patrapradeepk identificationoftherapeutictargetsforinflammationinsicklecelldiseasescdamongindianpatientsusinggeneexpressiondataanalysis

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