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Recent Improvement in the Long-term Survival of Breast Cancer Patients by Age and Stage in Japan
BACKGROUND: Recent improvements in 5-year survival of breast cancer have been reported in Japan and other countries. Though the number of long-term breast cancer survivors has been increasing, recent improvements in 10-year survival have not been reported. Moreover, the degree of improvement accordi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japan Epidemiological Association
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143379/ https://www.ncbi.nlm.nih.gov/pubmed/29479003 http://dx.doi.org/10.2188/jea.JE20170103 |
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author | Yoshimura, Akiyo Ito, Hidemi Nishino, Yoshikazu Hattori, Masakazu Matsuda, Tomohiro Miyashiro, Isao Nakayama, Tomio Iwata, Hiroji Matsuo, Keitaro Tanaka, Hideo Ito, Yuri |
author_facet | Yoshimura, Akiyo Ito, Hidemi Nishino, Yoshikazu Hattori, Masakazu Matsuda, Tomohiro Miyashiro, Isao Nakayama, Tomio Iwata, Hiroji Matsuo, Keitaro Tanaka, Hideo Ito, Yuri |
author_sort | Yoshimura, Akiyo |
collection | PubMed |
description | BACKGROUND: Recent improvements in 5-year survival of breast cancer have been reported in Japan and other countries. Though the number of long-term breast cancer survivors has been increasing, recent improvements in 10-year survival have not been reported. Moreover, the degree of improvement according to age and disease stage remains unclear. METHODS: We calculated long-term survival using data on breast cancer diagnosed from 1993 through 2006 from six prefectural population-based cancer registries in Japan. The recent increase in 10-year relative survival was assessed by comparing the results of period analysis in 2002–2006 with the results of cohort analysis in 1993–1997. We also conducted stratified analyses by age group (15–34, 35–49, 50–69, and 70–99 years) and disease stage (localized, regional, and distant). RESULTS: A total of 63,348 patients were analysed. Ten-year relative survival improved by 2.4% (76.9% vs 79.3%) from 1993 through 2006. By age and stage, 10-year relative survival clearly improved in the age 35–49 years (+2.9%; 78.1% vs 81.0%), 50–69 years (+2.8%; 75.2% vs 78.0%) and regional disease (+3.4%; 64.9% vs 68.3%). In contrast, the degree of improvement was small in the age 15–34 years (+0.1%; 68.2% vs 68.3%), 70–99 years (+1.0%; 87.6% vs 88.6%), localized disease (+1.1%; 92.6% vs 93.7%) and distant metastasis (+0.9%; 13.8% vs 14.7%). CONCLUSIONS: These population-based cancer registry data show that 10-year relative survival improved 2.4% over this period in Japan. By age and stage, improvement in the age 15–34 years and distant metastasis was very small, which suggests the need for new therapeutic strategies in these patients. |
format | Online Article Text |
id | pubmed-6143379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Japan Epidemiological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-61433792018-10-05 Recent Improvement in the Long-term Survival of Breast Cancer Patients by Age and Stage in Japan Yoshimura, Akiyo Ito, Hidemi Nishino, Yoshikazu Hattori, Masakazu Matsuda, Tomohiro Miyashiro, Isao Nakayama, Tomio Iwata, Hiroji Matsuo, Keitaro Tanaka, Hideo Ito, Yuri J Epidemiol Original Article BACKGROUND: Recent improvements in 5-year survival of breast cancer have been reported in Japan and other countries. Though the number of long-term breast cancer survivors has been increasing, recent improvements in 10-year survival have not been reported. Moreover, the degree of improvement according to age and disease stage remains unclear. METHODS: We calculated long-term survival using data on breast cancer diagnosed from 1993 through 2006 from six prefectural population-based cancer registries in Japan. The recent increase in 10-year relative survival was assessed by comparing the results of period analysis in 2002–2006 with the results of cohort analysis in 1993–1997. We also conducted stratified analyses by age group (15–34, 35–49, 50–69, and 70–99 years) and disease stage (localized, regional, and distant). RESULTS: A total of 63,348 patients were analysed. Ten-year relative survival improved by 2.4% (76.9% vs 79.3%) from 1993 through 2006. By age and stage, 10-year relative survival clearly improved in the age 35–49 years (+2.9%; 78.1% vs 81.0%), 50–69 years (+2.8%; 75.2% vs 78.0%) and regional disease (+3.4%; 64.9% vs 68.3%). In contrast, the degree of improvement was small in the age 15–34 years (+0.1%; 68.2% vs 68.3%), 70–99 years (+1.0%; 87.6% vs 88.6%), localized disease (+1.1%; 92.6% vs 93.7%) and distant metastasis (+0.9%; 13.8% vs 14.7%). CONCLUSIONS: These population-based cancer registry data show that 10-year relative survival improved 2.4% over this period in Japan. By age and stage, improvement in the age 15–34 years and distant metastasis was very small, which suggests the need for new therapeutic strategies in these patients. Japan Epidemiological Association 2018-10-05 /pmc/articles/PMC6143379/ /pubmed/29479003 http://dx.doi.org/10.2188/jea.JE20170103 Text en © 2018 Akiyo Yoshimura et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Article Yoshimura, Akiyo Ito, Hidemi Nishino, Yoshikazu Hattori, Masakazu Matsuda, Tomohiro Miyashiro, Isao Nakayama, Tomio Iwata, Hiroji Matsuo, Keitaro Tanaka, Hideo Ito, Yuri Recent Improvement in the Long-term Survival of Breast Cancer Patients by Age and Stage in Japan |
title | Recent Improvement in the Long-term Survival of Breast Cancer Patients by Age and Stage in Japan |
title_full | Recent Improvement in the Long-term Survival of Breast Cancer Patients by Age and Stage in Japan |
title_fullStr | Recent Improvement in the Long-term Survival of Breast Cancer Patients by Age and Stage in Japan |
title_full_unstemmed | Recent Improvement in the Long-term Survival of Breast Cancer Patients by Age and Stage in Japan |
title_short | Recent Improvement in the Long-term Survival of Breast Cancer Patients by Age and Stage in Japan |
title_sort | recent improvement in the long-term survival of breast cancer patients by age and stage in japan |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143379/ https://www.ncbi.nlm.nih.gov/pubmed/29479003 http://dx.doi.org/10.2188/jea.JE20170103 |
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