SIRT1 activation attenuates α cell hyperplasia, hyperglucagonaemia and hyperglycaemia in STZ-diabetic mice

The NAD(+)-dependent lysine deacetylase, Sirtuin 1 (SIRT1), plays a central role in metabolic regulation. With type 1 diabetes a disease that is characterised by metabolic dysregulation, we sought to assess the impact of SIRT1 activation in experimental, streptozotocin (STZ)-induced diabetes. CD1 mi...

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Detalles Bibliográficos
Autores principales: Zhang, Yanling, Thai, Kerri, Jin, Tianru, Woo, Minna, Gilbert, Richard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143559/
https://www.ncbi.nlm.nih.gov/pubmed/30228292
http://dx.doi.org/10.1038/s41598-018-32351-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143559/
https://www.ncbi.nlm.nih.gov/pubmed/30228292
http://dx.doi.org/10.1038/s41598-018-32351-z

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