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SIRT1 activation attenuates α cell hyperplasia, hyperglucagonaemia and hyperglycaemia in STZ-diabetic mice

The NAD(+)-dependent lysine deacetylase, Sirtuin 1 (SIRT1), plays a central role in metabolic regulation. With type 1 diabetes a disease that is characterised by metabolic dysregulation, we sought to assess the impact of SIRT1 activation in experimental, streptozotocin (STZ)-induced diabetes. CD1 mi...

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Detalles Bibliográficos
Autores principales:	Zhang, Yanling, Thai, Kerri, Jin, Tianru, Woo, Minna, Gilbert, Richard E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143559/ https://www.ncbi.nlm.nih.gov/pubmed/30228292 http://dx.doi.org/10.1038/s41598-018-32351-z

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