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Saliva as a source of reagent to study human susceptibility to avian influenza H7N9 virus infection

Avian influenza H7N9 viruses are an important public health concern due to their high mortality rate and potentials for future pandemics. We investigated human susceptibility to H7N9 viruses using recombinant H7N9 hemagglutinin (HA) proteins as a probe and found a strong association between H7N9 inf...

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Autores principales: Tan, Ming, Cui, Lunbiao, Huo, Xiang, Xia, Ming, Shi, Fengjuan, Zeng, Xiaoyan, Huang, Pengwei, Zhong, Weiming, Li, Weiwei, Xu, Ke, Chen, Liling, Zhou, Minghao, Jiang, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143562/
https://www.ncbi.nlm.nih.gov/pubmed/30228261
http://dx.doi.org/10.1038/s41426-018-0160-8
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author Tan, Ming
Cui, Lunbiao
Huo, Xiang
Xia, Ming
Shi, Fengjuan
Zeng, Xiaoyan
Huang, Pengwei
Zhong, Weiming
Li, Weiwei
Xu, Ke
Chen, Liling
Zhou, Minghao
Jiang, Xi
author_facet Tan, Ming
Cui, Lunbiao
Huo, Xiang
Xia, Ming
Shi, Fengjuan
Zeng, Xiaoyan
Huang, Pengwei
Zhong, Weiming
Li, Weiwei
Xu, Ke
Chen, Liling
Zhou, Minghao
Jiang, Xi
author_sort Tan, Ming
collection PubMed
description Avian influenza H7N9 viruses are an important public health concern due to their high mortality rate and potentials for future pandemics. We investigated human susceptibility to H7N9 viruses using recombinant H7N9 hemagglutinin (HA) proteins as a probe and found a strong association between H7N9 infections and HA binding among saliva samples from 32 patients and 60 uninfected controls in Jiangsu province, China, during the 2016 epidemic season. We also found that sialyl Le(x) (SLe(x)) antigen that was recognized by H7N9 HA was associated with H7N9 virus infection. Further analysis suggested that additional saccharide residues adjacent to the SLe(x) moiety may affect the H7N9-binding specificity. Our data suggested that saliva may be a useful reagent to study human susceptibility to avian influenza H7N9 virus, which may impact the disease control and prevention of avian influenza viruses as important human pathogens.
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spelling pubmed-61435622018-09-21 Saliva as a source of reagent to study human susceptibility to avian influenza H7N9 virus infection Tan, Ming Cui, Lunbiao Huo, Xiang Xia, Ming Shi, Fengjuan Zeng, Xiaoyan Huang, Pengwei Zhong, Weiming Li, Weiwei Xu, Ke Chen, Liling Zhou, Minghao Jiang, Xi Emerg Microbes Infect Article Avian influenza H7N9 viruses are an important public health concern due to their high mortality rate and potentials for future pandemics. We investigated human susceptibility to H7N9 viruses using recombinant H7N9 hemagglutinin (HA) proteins as a probe and found a strong association between H7N9 infections and HA binding among saliva samples from 32 patients and 60 uninfected controls in Jiangsu province, China, during the 2016 epidemic season. We also found that sialyl Le(x) (SLe(x)) antigen that was recognized by H7N9 HA was associated with H7N9 virus infection. Further analysis suggested that additional saccharide residues adjacent to the SLe(x) moiety may affect the H7N9-binding specificity. Our data suggested that saliva may be a useful reagent to study human susceptibility to avian influenza H7N9 virus, which may impact the disease control and prevention of avian influenza viruses as important human pathogens. Nature Publishing Group UK 2018-09-19 /pmc/articles/PMC6143562/ /pubmed/30228261 http://dx.doi.org/10.1038/s41426-018-0160-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tan, Ming
Cui, Lunbiao
Huo, Xiang
Xia, Ming
Shi, Fengjuan
Zeng, Xiaoyan
Huang, Pengwei
Zhong, Weiming
Li, Weiwei
Xu, Ke
Chen, Liling
Zhou, Minghao
Jiang, Xi
Saliva as a source of reagent to study human susceptibility to avian influenza H7N9 virus infection
title Saliva as a source of reagent to study human susceptibility to avian influenza H7N9 virus infection
title_full Saliva as a source of reagent to study human susceptibility to avian influenza H7N9 virus infection
title_fullStr Saliva as a source of reagent to study human susceptibility to avian influenza H7N9 virus infection
title_full_unstemmed Saliva as a source of reagent to study human susceptibility to avian influenza H7N9 virus infection
title_short Saliva as a source of reagent to study human susceptibility to avian influenza H7N9 virus infection
title_sort saliva as a source of reagent to study human susceptibility to avian influenza h7n9 virus infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143562/
https://www.ncbi.nlm.nih.gov/pubmed/30228261
http://dx.doi.org/10.1038/s41426-018-0160-8
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