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Association between resistin and fibroblast growth factor 23 in patients with type 2 diabetes mellitus
Fibroblast growth factor 23 (FGF23) is associated with cardiovascular disease and all-cause mortality in patients with diabetes mellitus. Insulin resistance has recently been reported to increase FGF23 levels, and resistin is a peptide that mainly regulates insulin resistance. However, few studies h...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143599/ https://www.ncbi.nlm.nih.gov/pubmed/30228288 http://dx.doi.org/10.1038/s41598-018-32432-z |
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author | Nakashima, Akio Yokoyama, Keitaro Kawanami, Daiji Ohkido, Ichiro Urashima, Mitsuyoshi Utsunomiya, Kazunori Yokoo, Takashi |
author_facet | Nakashima, Akio Yokoyama, Keitaro Kawanami, Daiji Ohkido, Ichiro Urashima, Mitsuyoshi Utsunomiya, Kazunori Yokoo, Takashi |
author_sort | Nakashima, Akio |
collection | PubMed |
description | Fibroblast growth factor 23 (FGF23) is associated with cardiovascular disease and all-cause mortality in patients with diabetes mellitus. Insulin resistance has recently been reported to increase FGF23 levels, and resistin is a peptide that mainly regulates insulin resistance. However, few studies have investigated the association between FGF23 and resistin. A total of 422 patients with diabetes mellitus were recruited for this cross-sectional study to examine the association between resistin and intact FGF23. The mean ( ± standard deviation) age was 63.1 ± 11.9 years, and the median HbA1c was 6.7% (range, 6.1–7.1%). The mean estimated glomerular filtration rate (eGFR) was 66.2 ± 23.1 mL/min/m(2). Multiple regression analysis for resistin showed that logFGF23 (coefficient (Coef): 1.551; standard error (SE): 0.739; P = 0.036), C-peptide (Coef: 0.798; SE: 0.229; P = 0.001), ghrelin (Coef: 1.061; SE: 0.332; P = 0.001), intact parathyroid hormone (Coef: 0.022; SE: 0.099; P = 0.030), and eGFR (Coef: −0.091; SE: 0.017; P < 0.001) were all significantly associated with the resistin level. These associations were modified in patients with higher age, lower body mass index, and higher vitamin D levels. These results suggest that resistin is positively associated with serum FGF23 levels. |
format | Online Article Text |
id | pubmed-6143599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61435992018-09-24 Association between resistin and fibroblast growth factor 23 in patients with type 2 diabetes mellitus Nakashima, Akio Yokoyama, Keitaro Kawanami, Daiji Ohkido, Ichiro Urashima, Mitsuyoshi Utsunomiya, Kazunori Yokoo, Takashi Sci Rep Article Fibroblast growth factor 23 (FGF23) is associated with cardiovascular disease and all-cause mortality in patients with diabetes mellitus. Insulin resistance has recently been reported to increase FGF23 levels, and resistin is a peptide that mainly regulates insulin resistance. However, few studies have investigated the association between FGF23 and resistin. A total of 422 patients with diabetes mellitus were recruited for this cross-sectional study to examine the association between resistin and intact FGF23. The mean ( ± standard deviation) age was 63.1 ± 11.9 years, and the median HbA1c was 6.7% (range, 6.1–7.1%). The mean estimated glomerular filtration rate (eGFR) was 66.2 ± 23.1 mL/min/m(2). Multiple regression analysis for resistin showed that logFGF23 (coefficient (Coef): 1.551; standard error (SE): 0.739; P = 0.036), C-peptide (Coef: 0.798; SE: 0.229; P = 0.001), ghrelin (Coef: 1.061; SE: 0.332; P = 0.001), intact parathyroid hormone (Coef: 0.022; SE: 0.099; P = 0.030), and eGFR (Coef: −0.091; SE: 0.017; P < 0.001) were all significantly associated with the resistin level. These associations were modified in patients with higher age, lower body mass index, and higher vitamin D levels. These results suggest that resistin is positively associated with serum FGF23 levels. Nature Publishing Group UK 2018-09-18 /pmc/articles/PMC6143599/ /pubmed/30228288 http://dx.doi.org/10.1038/s41598-018-32432-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Nakashima, Akio Yokoyama, Keitaro Kawanami, Daiji Ohkido, Ichiro Urashima, Mitsuyoshi Utsunomiya, Kazunori Yokoo, Takashi Association between resistin and fibroblast growth factor 23 in patients with type 2 diabetes mellitus |
title | Association between resistin and fibroblast growth factor 23 in patients with type 2 diabetes mellitus |
title_full | Association between resistin and fibroblast growth factor 23 in patients with type 2 diabetes mellitus |
title_fullStr | Association between resistin and fibroblast growth factor 23 in patients with type 2 diabetes mellitus |
title_full_unstemmed | Association between resistin and fibroblast growth factor 23 in patients with type 2 diabetes mellitus |
title_short | Association between resistin and fibroblast growth factor 23 in patients with type 2 diabetes mellitus |
title_sort | association between resistin and fibroblast growth factor 23 in patients with type 2 diabetes mellitus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143599/ https://www.ncbi.nlm.nih.gov/pubmed/30228288 http://dx.doi.org/10.1038/s41598-018-32432-z |
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